The stereoselective total synthesis of (-)-achaetolide

被引：11

作者：

Thakur, Pallavi ^{[1
]}

Kumaraswamy, Boyapelly ^{[1
]}

Reddy, Gurram Raji ^{[1
]}

Bandichhor, Rakeshwar ^{[2
]}

Mukkantii, Khagga ^{[3
]}

机构：

[1] Maithili Life Sci Pvt Ltd, IDA, Hyderabad 500076, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, IPD, Qutubullapur 500073, Andhra Pradesh, India

[3] JNT Univ, Ctr Environm Sci, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 08期

关键词：

POTENTIAL MYCOHERBICIDE; PHYTOTOXIC NONENOLIDE; STAGONOSPORA-CIRSII; ALDOL ADDITIONS; ACHAETOLIDE; LACTONE; AUXILIARIES; MACROLIDES; MODIOLIDE;

D O I：

10.1016/j.tetasy.2012.03.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The stereoselective total synthesis of (-)-achaetolide is described in a convergent manner. Grignard addition, Wittig homologation, acetate aldol and ring closing metathesis reactions were the key steps involved. The required olefinic alcohol fragments were synthesized from a single chiral pool material 2-deoxy-D-ribose and olefinic acid fragment was prepared from acetate aldol reaction. Both the olefinic acid and alcohols were prepared in a concise method. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：547 / 553

页数：7

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