Is T-wave alternans T-wave amplitude dependent?

被引：10

作者：

Burattini, Laura ^{[1
]}

Zareba, Wojciech ^{[2
,3
]}

Burattini, Roberto ^{[1
]}

机构：

[1] Polytech Univ Marche, Dept Biomed Elect & Telecommun Engn, I-60131 Ancona, Italy

[2] Univ Rochester, Dept Med, Cardiol Unit, Heart Res Follow Up Program, Rochester, NY USA

[3] Univ Rochester, Dept Biomed Engn, Rochester, NY USA

来源：

BIOMEDICAL SIGNAL PROCESSING AND CONTROL | 2012年 / 7卷 / 04期

关键词：

ECG repolarization; T-wave variability; ECG signal processing; LEFT-VENTRICULAR DYSFUNCTION; CORONARY-ARTERY-DISEASE; SUDDEN CARDIAC DEATH; LONG QT SYNDROME; MYOCARDIAL-INFARCTION; ELECTRICAL ALTERNANS; ARRHYTHMIC EVENTS; REPOLARIZATION ALTERNANS; PREDICTIVE-VALUE; HIGH-RISK;

D O I：

10.1016/j.bspc.2011.06.009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The possible dependence of T-wave alternans (TWA) on T-wave amplitude was investigated in 3 orthogonal leads (X, Y, Z) 20-min resting ECG recordings and in the derived vector magnitude (VM) from 176 healthy (H) subjects and 200 coronary-artery-disease (CAD) patients. After application of our adaptive-match-filter based method for parameterization of TWA in terms of its amplitude (TWA_A) and product-magnitude (TWA_PM, defined as the product of TWA_A times TWA duration), and once a TW_A parameter was defined for T-wave amplitude quantification, the existence of intra- and inter-subjects relationships of TWA_A and TWA_PM vs. TWA was tested. Compared to the H-population, the CAD-population showed a significant (P<0.05) increase of TWA_A (62 +/- 38 mu V vs. 54 +/- 25 mu V) and TWA_PM (4029 +/- 2974 beat mu V vs. 3107 +/- 1976 beat mu V) and a significant decrease of TW_A (298 +/- 194 mu V vs. 467 +/- 246 mu V). These repolarization changes, however, occurred with no significant intra- or inter-subjects relationships of TWA_A and TWA_PM vs. TW_A. Thus, in our CAD and H populations there was no evidence of TWA dependence on T-wave amplitude. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：358 / 364

页数：7

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