Serum neurofilament light chain and postural instability/gait difficulty (PIGD) subtypes of Parkinson's disease in the MARK-PD study

被引：10
|
作者：
Poetter-Nerger, Monika [1 ]
Dutke, Janina [1 ]
Lezius, Susanne [2 ]
Buhmann, Carsten [1 ]
Schulz, Robert [1 ]
Gerloff, Christian [1 ]
Kuhle, Jens [3 ]
Choe, Chi-un [1 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Martinistr 52, D-20246 Hamburg, Germany
[2] Univ Med Ctr Hamburg Eppendorf, Inst Biometry & Med Epidemiol, Hamburg, Germany
[3] Univ Basel, Dept Neurol, Basel, Switzerland
来源：
JOURNAL OF NEURAL TRANSMISSION | 2022年 / 129卷 / 03期
关键词：
MDS-UPDRS; Hoehn and Yahr; MoCA; Biomarker; NFL;
D O I：
10.1007/s00702-022-02464-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The PIGD (postural instability / gait difficulty) subtype of Parkinson ' s disease (PD) is associated with faster cognitive and motor decline. So far, there are no quantifiable biomarkers to aid clinical subtyping. Neurofilament light chain (NfL) is a highly specific marker of neuro-axonal damage and can be assessed in blood. Here, we investigated if serum NfL concentrations are associated with PIGD subtype and PIGD scores in PD patients at advanced disease stages. Furthermore, we evaluated if serum NfL is associated with motor and cognitive function assessed with MDS-UPDRS part III and Montreal cognitive assessment (MoCA). Serum NfL levels were analyzed with Single Molecule Assays (Simoa) in blood of 223 PD patients from the bioMARKers in Parkinson's Disease (MARK-PD) study. Serum NfL concentrations were higher in PIGD patients independent of age, sex and disease duration. In linear regression analysis, serum NfL levels were associated with MoCA, MDS-UPDRS III and PIGD scores in unadjusted models, but remained significant after adjustment only with PIGD scores. In conclusion, increased serum NfL levels were associated with PIGD subtype and PIGD scores in patients with advanced PD.
引用
收藏
页码：295 / 300
页数：6
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