Evolution of Clinical Proteomics and its Role in Medicine

被引：46

作者：

Boja, Emily ^{[1
]}

Hiltke, Tara ^{[1
]}

Rivers, Robert ^{[1
]}

Kinsinger, Christopher ^{[1
]}

Rahbar, Amir ^{[1
]}

Mesri, Mehdi ^{[1
]}

Rodriguez, Henry ^{[1
]}

机构：

[1] NCI, Off Canc Clin Prote Res, Ctr Strateg Sci Initiat, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2011年 / 10卷 / 01期

关键词：

biomarker; clinical proteomics; protein quantitation; post-translational modifications; multiple reaction monitoring mass spectrometry; enzyme-linked immunosorbent assay; immunohistochemistry; flow cytometry; nanotechnology; verification; qualification; genomics; The Cancer Genome Atlas; TANDEM MASS-SPECTROMETRY; CODED AFFINITY TAGS; ISOBARIC TAGGING REAGENTS; COMPLEX PROTEIN MIXTURES; LABEL-FREE; QUANTITATIVE PROTEOMICS; BIOMARKER DISCOVERY; ABSOLUTE QUANTIFICATION; 2-DIMENSIONAL ELECTROPHORESIS; PEPTIDE IDENTIFICATION;

D O I：

10.1021/pr100532g

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant progress has been made in characterizing and sequencing genomic alterations of biospecimens from several types of cancer. Understanding the functional changes in the human proteome that arise from the genomic alterations or other factors is the next logical step in the development of high-value protein biomarkers that can be transitioned to clinical studies for biomarker qualification. Linking advances in genomic analysis to proteomic analysis will provide a pathway for qualified biomarkers which can drive the rational development of new diagnostics and therapies. The availability of these multidimensional data to the scientific community sets the stage for the development of new molecularly targeted cancer interventions.

引用

页码：66 / 84

页数：19

共 50 条

[21] Implementation of Clinical Proteomics: A Step Closer to Personalized Medicine?
Vlahou, Antonia
PROTEOMICS CLINICAL APPLICATIONS, 2019, 13 (02)
[22] Clinical Proteomics for Precision Medicine: The Bladder Cancer Case
Latosinska, Agnieszka
Frantzi, Maria
Vlahou, Antonia
Merseburger, Axel S.
Mischak, Harald
PROTEOMICS CLINICAL APPLICATIONS, 2018, 12 (02)
[23] EVOLUTION OF CLINICAL METHODS IN MEDICINE
不详
BRITISH JOURNAL OF SURGERY, 1965, 52 (04) : 318 - &
[24] The Institute on Human Values in Medicine: Its role and influence in the conception and evolution of bioethics
McElhinney, TK
Pellegrino, ED
THEORETICAL MEDICINE AND BIOETHICS, 2001, 22 (04) : 291 - 317
[25] The Institute on Human Values in Medicine: Its Role and Influence in the Conception and Evolution of Bioethics
Thomas K. McElhinney
Edmund D. Pellegrino
Theoretical Medicine and Bioethics, 2001, 22 : 291 - 317
[26] CLINICAL QUALITY IN NUCLEAR-MEDICINE - ROC ANALYSIS AND ITS ROLE
VERNON, P
BRITISH JOURNAL OF RADIOLOGY, 1978, 51 (610): : 839 - 839
[27] Thrombopoietin: its role in platelet disorders and as a new drug in clinical medicine
von dem Borne, AEGK
Folman, C
Linthorst, GE
Porcelijn, L
van den Oudenrijn, S
van der Schoot, E
de Haas, M
BAILLIERES CLINICAL HAEMATOLOGY, 1998, 11 (02): : 427 - 445
[28] The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery
Edwards, Alistair V. G.
White, Melanie Y.
Cordwell, Stuart J.
MOLECULAR & CELLULAR PROTEOMICS, 2008, 7 (10) : 1824 - 1837
[29] Proteomics and its role in drug discovery and development
Nishimura, T
SEIKAGAKU, 2004, 76 (10): : 1344 - 1352
[30] Clinical proteomics and OMICS clues useful in translational medicine research
Elena López
Luis Madero
Juan López-Pascual
Martin Latterich
Proteome Science, 10

← 1 2 3 4 5 →