Stereoselective TiCl4-Mediated Aldol Reactions Starting from Acylsilanes

被引：4

作者：

Marri, Gangababu ^{[1
]}

Reddy, J. Satyanarayana ^{[1
]}

Ruiz, Johal ^{[2
]}

Das, Saibal ^{[1
]}

Gree, Rene ^{[2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] Univ Rennes 1, Inst Sci Chim Rennes, CNRS, UMR 6226, F-35042 Rennes, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 04期

关键词：

Silanes; Aldol reactions; Silicon; Lewis acids; ADDITIONS; REAGENTS; ASSEMBLAGE; MECHANISM; ALDEHYDES; ACETATES; SYN;

D O I：

10.1002/ejoc.201403263

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for the preparation of beta-hydroxyacylsilanes has been developed through a TiCl4-mediated aldol reaction. A selection of Lewis acids has been assessed, and other parameters such as solvent and temperature have been optimized. These aldol reactions occur under mild conditions and furnish a selection of beta-hydroxy acylsilanes in fair-to-good yields with high syn selectivities (up to 99%).

引用

页码：840 / 846

页数：7

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