A new view on p53 protein cytoplasmic sequestration

被引：0

作者：

Douc-Rasy, S ^{[1
]}

Bénard, J ^{[1
]}

机构：

[1] Inst Gustave Roussy, Dept Biol Clin, Unite Marquers Genet Canc, UMR CNRS 8126, F-94805 Villejuif, France

来源：

BULLETIN DU CANCER | 2003年 / 90卷 / 05期

关键词：

p53; Parc; cytoplasmic protein;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In human tumors, p53 inactivation occurs frequently by mutation, and possibly also by nuclear exclusion of wt p53. First reported by Uta Moll in 1992, p53 "cytoplasmic sequestration" has been thoroughly studied to elucidate molecular mechanism of this process, using neuroblastoma cell lines as model, An American team at the Columbia University has just isolated the cytoplasmic protein Parc (Nikolaev, Cell 20031 which specifically binds to P53 and anchors it, so that the "guardian of the genome" cannot play its role in the nucleus. AntiParc siRNA-manipulation relocates p53 into the nucleus, restitutes a function to p53 and chemo-radiosensitivity to malignant neuroblasts.

引用

页码：380 / 382

页数：3

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