Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence

PurposeTo describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis.MethodsCase report.ResultsWe describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement. She received adjuvant chemotherapy with topical Interferon alpha2b (3 cycles) for positive margins. Six months after treatment, she is completely tumor free.ConclusionCo-occurrence of OSSN and chronic fungal keratitis is rare. We recommend that patients with chronic ocular infections should be examined and followed closely for abnormally thickened limbal areas.