Decreasing pfmdr1 Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining In Vitro Susceptibility to Mefloquine

被引：28
|
作者：
Lim, Pharath [1 ,2 ]
Dek, Dalin [2 ]
Try, Vorleak [2 ]
Sreng, Sokunthea [2 ]
Suon, Seila [2 ]
Fairhurst, Rick M. [1 ]
机构：
[1] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA
[2] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 05期
关键词：
DIHYDROARTEMISININ-PIPERAQUINE; ARTEMETHER-LUMEFANTRINE; ARTEMISININ RESISTANCE; ARTESUNATE-MEFLOQUINE; COMBINATION THERAPY; MALARIA; CHLOROQUINE; EFFICACY; FAILURE; SENSITIVITY;
D O I：
10.1128/AAC.05163-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS + MQ) as a replacement ACT, we measured the prevalence of multiple pfmdr1 copies-a molecular marker for MQ resistance-in 844 P. falciparum clinical isolates collected in 2008 to 2013. The pfmdr1 copy number is decreasing in Western Cambodia, suggesting that P. falciparum is regaining in vitro susceptibility to MQ.
引用
收藏
页码：2934 / 2937
页数：4
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