Leptin receptor immunoreactivity in sympathetic prevertebral ganglion neurons of mouse and rat

被引：10

作者：

Miller, SM

Schmalz, PF

Benarroch, EE

Szurszewski, JH

机构：

[1] Mayo Clin & Mayo Fdn, Dept Physiol & Biophys, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA

来源：

NEUROSCIENCE LETTERS | 1999年 / 265卷 / 02期

关键词：

leptin receptors; prevertebral ganglia; sympathetic nervous system; immunohistochemistry; obesity;

D O I：

10.1016/S0304-3940(99)00215-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prevertebral ganglia, comprising the inferior mesenteric, superior mesenteric and celiac ganglia, contain the cell bodies of sympathetic neurons that regulate gastrointestinal motility, visceral blood flow, secretion and absorption. In the present study, we report the presence of leptin receptor-like immunoreactivity in the superior mesenteric and celiac ganglia of mice and rats. Ganglion neurons were immunopositive for leptin receptor. Confocal microscopy and three-dimensional (3-D) reconstruction of ganglion neurons filled with Lucifer yellow and then immunostained for leptin receptor showed that leptin receptor immunoreactivity was intracellular and that it was present on structures encircling the nucleus. These results raise the possibility that leptin may affect gastrointestinal function by acting on leptin receptors located in prevertebral ganglion neurons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：75 / 78

页数：4

共 50 条

[41] Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain
Yarnell, DO
Knight, DS
Hamilton, K
Tulp, O
Tso, P
[J]. BRAIN RESEARCH, 1998, 785 (01) : 80 - 90
[42] Detection of α2A- and β-adrenergic receptor immunoreactivity in cultured sympathetic neurons.
Shivachar, AC
Eikenburg, DC
[J]. FASEB JOURNAL, 1999, 13 (04): : A142 - A142
[43] Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons
Burman, KJ
McKitrick, DJ
Minson, JB
West, A
Arnolda, LF
Llewellyn-Smith, IJ
[J]. BRAIN RESEARCH, 2001, 915 (02) : 238 - 243
[44] Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons
Rivas-Ramirez, P.
Cadaveira-Mosquera, A.
Lamas, J. A.
Reboreda, A.
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2015, 42 (02) : 1797 - 1807
[45] CONNECTIONS BETWEEN NEURONS OF SYMPATHETIC GANGLION
SKOK, VI
[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE,USSR, 1966, 61 (03): : 232 - &
[46] Interaction between parasympathetic and sympathetic nerves in prevertebral ganglia: Morphological evidence for vagal efferent innervation of ganglion cells in the rat
Berthoud, HR
Powley, TL
[J]. MICROSCOPY RESEARCH AND TECHNIQUE, 1996, 35 (01) : 80 - 86
[47] GLUCOCORTICOID RECEPTOR IMMUNOREACTIVITY IN MONOAMINERGIC NEURONS OF RAT-BRAIN
HARFSTRAND, A
FUXE, K
CINTRA, A
AGNATI, LF
ZINI, I
WIKSTROM, AC
OKRET, S
YU, ZY
GOLDSTEIN, M
STEINBUSCH, H
VERHOFSTAD, A
GUSTAFSSON, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) : 9779 - 9783
[48] Disassembly of the cholinergic postsynaptic apparatus induced by axotomy in mouse sympathetic neurons:: The loss of dystrophin and β-dystroglycan immunoreactivity precedes that of the acetylcholine receptor
Zaccaria, ML
De Stefano, ME
Properzi, F
Gotti, C
Petrucci, TC
Paggi, P
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (08): : 768 - 779
[49] Reflex patterns in preganglionic sympathetic neurons projecting to the superior cervical ganglion in the rat
Bartsch, T
Jänig, W
Häbler, HJ
[J]. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2000, 83 (1-2): : 66 - 74
[50] Effects of Equine Grass Sickness on Sympathetic Neurons in Prevertebral and Paravertebral Ganglia
Shotton, H. R.
Lincoln, J.
McGorum, B. C.
[J]. JOURNAL OF COMPARATIVE PATHOLOGY, 2011, 145 (01) : 35 - 44

← 1 2 3 4 5 →