Complexes of N- and O-Donor Ligands as Potential Urease Inhibitors

被引：10

作者：

Shah, Syed Raza ^{[1
,2
]}

Shah, Zarbad ^{[2
]}

Khiat, Mohammed ^{[1
]}

Khan, Ajmal ^{[1
]}

Hill, Leila R. ^{[3
]}

Khan, Shakeel ^{[2
]}

Hussain, Javid ^{[5
]}

Csuk, Rene ^{[4
]}

Anwar, Muhammad U. ^{[1
]}

Al-Harrasi, Ahmed ^{[1
]}

机构：

[1] Univ Nizwa, Nat & Med Scicnces Res Ctr, Nizwa 616, Oman

[2] Bacha Khan Univ Charsadda, Dept Chem, Charsadda 24420, Khyber Pakhtunk, Pakistan

[3] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[4] Martin Luther Univ Halle Wittenberg, Organ Chem, D-06120 Halle, Saale, Germany

[5] Univ Nizwa, Dept Biol Sci & Chem, Nizwa 616, Oman

来源：

ACS OMEGA | 2020年 / 5卷 / 17期

关键词：

METAL-COMPLEXES; BARBITURIC-ACID; ANTIBACTERIAL; ANTIOXIDANT; ANTITUMOR; WATER; IONS;

D O I：

10.1021/acsomega.0c01089

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (BTA), thiobarbituric acid (TBA), isoniazid (INZ), and nicotinamide (NCA) ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of analytical techniques including infra-red and UV-vis spectroscopy, H-1 NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. We describe two mononuclear complexes with a general formula {[M(NCA)(2)(H2O)(4)](BTA)(2)(H2O)}, where M = Co (1) and Zn (2), a mononuclear complex {[Ni(NCA)(2)(H2O)(4)](TBA)(2)(H2O)} (3), and two polymeric chains of a general formula {[M(INZ) (H2O)(3)](BTA)(2)(H2O)(3)}, where M = Co (4) and Zn (5). These complexes displayed significant urease enzyme inhibition with IC50 values in the range of 3.9-19.9 mu M.

引用

页码：10200 / 10206

页数：7

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