MATHEMATICAL AND COMPUTER MODELLING CONTROL MECHANISMS OF HIERARCHICAL MOLECULAR-GENETIC SYSTEMS

The progress achieved in biology during last century has led to development of mathematical and computer modelling control mechanisms in molecular-genetic processes in living systems. In this work we consider one of the possible methods for mathematical and computer modelling control mechanisms of hierarchical molecular-genetic systems. The corresponding equations (in the class of delay functional-differential equations) are developed, using the approaches by B.Goodwin, Bl. Sendov, M. Eigen, B.A. Ratner, and taking into account temporary relations, presence of multifunctional feedback and cooperative nature of processes in cell's regulatory loops. Results of using the considered method for analyzing cell's molecular-genetic systems in the presence of the alien genes (on the example of hepatic cell infections by hepatitis B virus) are given.