Four comparative experiments and some supplementary experiments were conducted to examine the role of meridional wind stress anomalies and heat flux variability in ENSO simulations by using a high-resolution Ocean General Circulation Model (OGCM). The results indicate that changes in the direction and magnitude of meridional wind stress anomalies have little influence on ENSO simulations until meridional wind stress anomalies are unrealistically enlarged by a factor of 5.0. However, evidence of an impact on ENSO simulations due to heat flux variability was found. The simulated Nino-3 index without the effect of heat flux anomalies tended to be around 1.0 degrees lower than the observed, as well as the control run, during the peak months of ENSO events.