Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats

被引：1
|
作者：
Azuma, A [1 ]
Sugimoto, Y [1 ]
Mio, M [1 ]
Shinomiya, K [1 ]
Kamei, C [1 ]
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2003年 / 25卷 / 03期
关键词：
Arg(8)]-vasopressin; blood pressure; hippocampus; regional cerebral blood flow; V-1 antagonist V-2 antagonist;
D O I：
10.1358/mf.2003.25.3.769639
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of [Arg(8)]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocamous. The effects of the metabolic fragments AVP4-9 and A VP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V-2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V-2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V-1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site. (C) 2003 Prous Science. All rights reserved.
引用
收藏
页码：193 / 197
页数：5
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