A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

被引：6
|
作者：
Casellas, Nicolas M. [1 ,2 ,3 ]
Dai, Gaole [4 ]
Xue, Evelyn Y. [4 ]
Fonseca, Alba [1 ,2 ]
Ng, Dennis K. P. [4 ]
Garcia-Iglesias, Miguel [1 ,2 ,3 ,5 ]
Torres, Tomas [1 ,2 ,3 ]
机构：
[1] Univ Autonoma Madrid, Dept Organ Chem, Calle Francisco Tomas y Valiente 7, Madrid 28049, Spain
[2] Univ Autonoma Madrid, Inst Adv Res Chem Sci IadChem, Calle Francisco Tomas y Valiente 7, Madrid 28049, Spain
[3] IMDEA Nanociencia, C Faraday 9, Madrid 28049, Spain
[4] Chinese Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China
[5] Univ Cantabria, QUIPRE Dept, Avd Los Castros 46, Santander 39005, Spain
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 05期
关键词：
PHOTOSENSITIZERS; DESIGN;
D O I：
10.1039/d1cc05977g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 mu M.
引用
收藏
页码：669 / 672
页数：4
相关论文
共 50 条
  • [31] Rationally designed porous self-assembled nanoparticles for combinational chemo-photodynamic therapy
    Negi, Kanchan
    Kumar, Ashok
    Chakraborty, Gourav
    Sahoo, Sudhansubala
    Patra, Sushmita
    Patra, Niladri
    Bhutia, Sujit Kumar
    Sahu, Sumanta Kumar
    DALTON TRANSACTIONS, 2024, 53 (43) : 17465 - 17479
  • [32] Porphyrin self-assembled monolayers and photodynamic oxidation of tryptophan
    Chambrier, Isabelle
    Russell, David A.
    Brundish, Derek E.
    Love, William G.
    Jori, Giulio
    Magaraggia, M.
    Cook, Michael J.
    JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 2010, 14 (01) : 81 - 88
  • [33] Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
    Wang, Dongdong
    Wu, Huihui
    Phua, Soo Zeng Fiona
    Yang, Guangbao
    Lim, Wei Qi
    Gu, Long
    Qian, Cheng
    Wang, Haibao
    Guo, Zhen
    Chen, Hongzhong
    Zhao, Yanli
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [34] Self-assembled supramolecular nanoparticles mediated by host-guest interactions for photodynamic therapy
    Yan, Hong
    Pan, Xiaoyong
    Chua, Ming Hui
    Wang, Xiaobai
    Song, Jing
    Ye, Qun
    Zhou, Hui
    Xuan, Angeline Tan Yan
    Liu, Ye
    Xu, Jianwei
    RSC ADVANCES, 2014, 4 (21) : 10708 - 10717
  • [35] Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
    Dongdong Wang
    Huihui Wu
    Soo Zeng Fiona Phua
    Guangbao Yang
    Wei Qi Lim
    Long Gu
    Cheng Qian
    Haibao Wang
    Zhen Guo
    Hongzhong Chen
    Yanli Zhao
    Nature Communications, 11
  • [36] Carrier-Enhanced Photodynamic Cancer Therapy of Self-Assembled Green Tea Polyphenol-Based Nanoformulations
    Chen, Xiangyu
    Yi, Zeng
    Chen, Guangcan
    Ma, Xiaomin
    Su, Wen
    Deng, Zhiwen
    Ma, Lei
    Tong, Qiulan
    Ran, Yaqin
    Li, Xudong
    ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2020, 8 (43) : 16372 - 16384
  • [37] Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy in vitro and in vivo
    Xu, Zi-Yue
    Mao, Weipeng
    Zhao, Zizhen
    Wang, Ze-Kun
    Liu, Yue-Yang
    Wu, Yan
    Wang, Hui
    Zhang, Dan-Wei
    Li, Zhan-Ting
    Ma, Da
    JOURNAL OF MATERIALS CHEMISTRY B, 2022, 10 (06) : 899 - 908
  • [38] Formation and photoinduced processes of a self-assembled subphthalocyanine-porphyrin-phthalocyanine supramolecular complex
    Menting, Roel
    Lau, Janet T. F.
    Xu, Hu
    Ng, Dennis K. P.
    Roeder, Beate
    Ermilov, Eugeny A.
    CHEMICAL COMMUNICATIONS, 2012, 48 (38) : 4597 - 4599
  • [39] Self-Assembly, Host-Guest Chemistry, and Photophysical Properties of Subphthalocyanine-Based Metallosupramolecular Capsules
    Sanchez-Molina, Irene
    Grimm, Bruno
    Calderon, Rafael M. Krick
    Claessens, Christian G.
    Guldi, Dirk M.
    Torres, Tomas
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (28) : 10503 - 10511
  • [40] Self-Assembled Carrier-Free Nanodrugs for Starvation Therapy-Amplified Photodynamic Therapy of Cancer
    Zhang, Dong-Yang
    Liang, Yuqin
    Wang, Mingcheng
    Younis, Muhammad Rizwan
    Yi, Huixi
    Zhao, Xiaoya
    Chang, Jishuo
    Zheng, Yue
    Guo, Weisheng
    Yu, Xiyong
    ADVANCED HEALTHCARE MATERIALS, 2023, 12 (20)
12345