Antioxidative activities of 4-hydroxy-3(2H)-furanones and their anti-cataract effect on spontaneous cataract rat (ICR/f)

被引：35
|
作者：
Sasaki, T
Yamakoshi, J
Saito, M
Kasai, K
Matsudo, T
Koga, T
Mori, K
机构：
[1] Kikkoman Foods Inc, Res & Dev Div, Noda, Chiba 2780037, Japan
[2] Noda Inst Sci Res, Noda, Chiba 2780037, Japan
[3] Tokyo Univ Sci, Dept Chem, Shinjuku Ku, Tokyo 1620825, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 10期
关键词：
furanone; anti-cataract; antioxidant; spontaneous cataract rat; ICR;
D O I：
10.1271/bbb.62.1865
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We determined the anti-cataract effects and antioxidative activities of four 4-hydroxy-3(2H)-furanones. These four furanones showed similar antioxidative activities in the ferric ion reduction model. 4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) and 2(or 5)-ethyl-4-hydroxy-5(or 2)-methyl-3(2H)-furanone (EHMF) exhibited a higher suppression effect on lipid peroxidation in human plasma than the other furanones did. The effects of hydroxy furanones on the onset of cataract in spontaneous cataract rat (ICR/f Fat) were tested, and it was observed that HDMF and EHMF inhibited cataract formation. These results suggest that the antioxidative activity of HDMF and EHMF against superoxide radicals in lens tissue contributed to inhibiting the onset of spontaneous cataract.
引用
收藏
页码：1865 / 1869
页数：5
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