Synthesis and anticancer evaluation of 2-phenyl thiaolidinone substituted 2-phenyl benzothiazole-6-carboxylic acid derivatives

被引：22

作者：

Prabhu, Padmavathi P. ^{[1
]}

Panneerselvam, T. ^{[2
]}

Shastry, C. S. ^{[3
]}

Sivakumar, A. ^{[4
]}

Pande, Sushant S. ^{[5
]}

机构：

[1] Srinivas Coll Pharm, Dept Pharmaceut Chem, Mangalore, Karnataka, India

[2] PESs Rajaram & Tarabai Bandekar Coll Pharm, Dept Pharmaceut Chem, Ponda, Goa, India

[3] NGSMIPS, Dept Pharmacol, Mangalore, Karnataka, India

[4] VIT Univ, Sch Bio Sci & Technol, Vellore, Tamil Nadu, India

[5] Govt Polytech Ratnagiri, Dept Pharm, Ratnagiri, Maharashtra, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2015年 / 19卷 / 02期

关键词：

Benzothiazole; Schiff bases; Thiazolidinones; Anticancer activity; HeLa cell lines; MTT assay; ANTITUMOR BENZOTHIAZOLES; POTENT; AGENT;

D O I：

10.1016/j.jscs.2012.02.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel series of 2-(3-(4-oxo-2-substituted phenyl thiazolidin-3-yl) phenyl) benzo[d] thiazole-6-carboxylic acid derivatives PP1-PP8 were synthesized by various benzothiazole Schiff's bases by reaction with thioglycollic acid. Their structures were established on the basis of IR, H-1-NMR, C-13-NMR, mass spectral data and elemental analysis. All the synthesized compounds were screened for their in vitro anticancer activity by 3-(4,5-dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) assay on human cervical cancer cell line (HeLa) cell lines. Among these compound PP2 exhibited most significant activity as compared with PP5, PP7 and PP8. However, the activity was less as compared to the standard drug Cisplatin. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：181 / 185

页数：5

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