High-Yield Fabrication of PLGA Non-Spherical Microarchitectures by Emulsion-Solvent Evaporation Method

被引：20

作者：

Li, Ruifeng ^{[1
]}

Li, Xuemin ^{[1
]}

Liu, Lingrong ^{[1
]}

Zhou, Zhimin ^{[1
]}

Tang, Hongbo ^{[1
]}

Zhang, Qiqing ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Biomed Engn, Peking Union Med Coll, Key Lab Biomed Mat Tianjin, Tianjin 300192, Peoples R China

[2] Xiamen Univ, Biomed Engn Res Ctr, Technol Res Ctr Biomed Engn Xiamen City, Key Lab Biomed Engn Fujian Prov, Xiamen 361005, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2010年 / 31卷 / 22期

关键词：

emulsion; high yield; non-spherical microarchitectures; PLGA; DRUG-DELIVERY; PARTICLES; MICROPARTICLES; COALESCENCE; DESIGN; SHAPE;

D O I：

10.1002/marc.201000332

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Recently, it has been recognized the shape of particles plays an essential role in the design of materials with unique properties. In this study, PLGA non-spherical microarchitectures, rods and fibers, were fabricated successfully in high yield by single emulsion-solvent evaporation method in the presence of sodium tripolyphosphate. The assay of PVA residue was carried out and the hydrogen bonds formation was verified as well. The presented data show that viscosity and coagulation agent have a synergistic effect on forming the rod- and fiber-like microarchitectures in the shear response and the formation mechanisms were proposed accordingly.

引用

页码：1981 / 1986

页数：6

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