Immunogenicity of Hepatitis B Vaccine in HIV Exposed Uninfected Infants

被引：4

作者：

Singh, Dharmendra K. ^{[1
]}

Kumar, Rajnish ^{[1
]}

Rai, Ruchi ^{[1
,3
]}

Maurya, Manisha ^{[1
]}

Bhargava, Anudita ^{[2
]}

机构：

[1] MLN Med Coll, Dept Pediat, Allahabad, Uttar Pradesh, India

[2] MLN Med Coll, Dept Microbiol, Allahabad, Uttar Pradesh, India

[3] SN Children Hosp, Church Lane, Allahabad 211002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF PEDIATRICS | 2016年 / 83卷 / 02期

关键词：

HBV; HIV exposed; Seroprotection; PREGNANT-WOMEN; ANTIBODY; VIRUS;

D O I：

10.1007/s12098-015-1905-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

There is paucity of knowledge about the immunogenicity of vaccines in infants who have been exposed to HIV in-utero but have remained uninfected. The authors studied the immunogenicity of 3 doses of recombinant hepatitis B vaccine at 6,10,14 wk of age in HIV exposed but uninfected (HEU) infants. After 3 mo of last dose of the vaccine, out of 26 infants, 23 (89.5 %) infants were found to be responders (Anti HBs IgG titres >= 10 mIU/ml) and 3 (11.5 %) babies remained non responders (Anti HBs IgG titres< 10 mIU/ml). The proportion of babies who were non responders were higher when compared to similar studies done on unexposed and uninfected infants, suggesting a poorer immunogenicity of hepatitis B vaccine in these infants.

引用

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页码：172 / 174

页数：3

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