Does glycosylation of lysosomal proteins show age-related changes in rat liver?

被引：16

作者：

Litynska, A ^{[1
]}

Przybylo, M ^{[1
]}

机构：

[1] Jagiellonian Univ, Inst Zool, PL-30060 Krakow, Poland

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1998年 / 102卷 / 01期

关键词：

rat liver; lysosomal glycoproteins; age-related changes;

D O I：

10.1016/S0047-6374(98)00006-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We studied the pattern of lectins binding by liver lysosomal proteins from rats between 18 days of gestation and 72 weeks of age. An analysis of the carbohydrate structure was carried out after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lectins. The only age-related differences were observed in the reaction with sialic acid-(MAA; Macckia amurensis, SNA; Sambucus nigra) and fucose-(AAA; Aleuria aurantia) specific lectins. Sialylation increased and fucosylation decreased with age. We also observed a specific reaction with Galanthus nivalis (GNA), Phaseolus vulgaris (PHA-L) and peanut agglutinin (PNA), without any significant changes with age. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 43

页数：11

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