A Decade of Combination Antiretroviral Treatment in Asia: The TREAT Asia HIV Observational Database Cohort

被引：0

作者：

Mean, C. V. ^{[1
,2
]}

Saphonn, V. ^{[1
,2
]}

Khol, V. ^{[1
,2
]}

Zhang, F. J. ^{[3
]}

Zhao, H. X. ^{[3
]}

Han, N. ^{[3
]}

Lee, M. P. ^{[4
]}

Li, P. C. K. ^{[4
]}

Lam, W. ^{[4
]}

Chan, Y. T. ^{[4
]}

Kumarasamy, N. ^{[5
]}

Saghayam, S. ^{[5
]}

Ezhilarasi, C. ^{[5
]}

Pujari, S.

Joshi, K. ^{[6
]}

Gaikwad, S. ^{[6
]}

Chitalikar, A. ^{[6
]}

Merati, T. P. ^{[7
,8
]}

Wirawan, D. N. ^{[7
,8
]}

Yuliana, F. ^{[7
,8
]}

Yunihastuti, E.

Imran, D. ^{[9
]}

Widhani, A. ^{[9
]}

Oka, S. ^{[10
]}

Tanuma, J. ^{[10
]}

Nishijima, T. ^{[10
]}

Choi, J. Y. ^{[11
]}

Na, S. ^{[11
]}

Kim, J. M. ^{[11
]}

Sim, B. L. H. ^{[12
]}

Gani, Y. M. ^{[12
]}

David, R. ^{[12
]}

Kamarulzaman, A. ^{[13
]}

Omar, S. F. Syed ^{[13
]}

Ponnampalavanar, S. ^{[13
]}

Azwa, I. ^{[13
]}

Mustafa, M. ^{[14
]}

Nordin, N. ^{[14
]}

Ditangco, R. ^{[15
]}

Uy, E. ^{[15
]}

Bantique, R. ^{[15
]}

Wong, W. W. ^{[16
]}

Ku, W. W. ^{[16
]}

Wu, P. C.

Ng, O. T. ^{[17
]}

Lim, P. L. ^{[17
]}

Lee, L. S. ^{[17
]}

Ohnmar, P. S. ^{[17
]}

Phanuphak, P. ^{[18
]}

Ruxrungtham, K. ^{[18
]}

机构：

[1] Natl Ctr HIV AIDS Dermatol & STDs, Phnom Penh, Cambodia

[2] Univ Hlth Sci, Phnom Penh, Cambodia

[3] Capital Med Univ, Beijing Ditan Hosp, Beijing, Peoples R China

[4] Queen Elizabeth Hosp, Hong Kong, Hong Kong, Peoples R China

[5] VHS, YRGCARE Med Ctr, CART CRS, Chennai, Tamil Nadu, India

[6] Inst Infect Dis, Pune, Maharashtra, India

[7] Udayana Univ, Fac Med, Bali, Indonesia

[8] Sanglah Hosp, Bali, Indonesia

[9] Univ Indonesia, Cipto Mangunkusumo Hosp, Fac Med, Working Grp AIDS, Jakarta, Indonesia

[10] Natl Ctr Global Hlth & Med, Tokyo, Japan

[11] Yonsei Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea

[12] Hosp Sungai Buloh, Sungai Buloh, Malaysia

[13] Univ Malaya, Med Ctr, Kuala Lumpur, Malaysia

[14] Hosp Rajaempuan Zainab II, Kota Baharu, Malaysia

[15] Res Inst Trop Med, Manila, Philippines

[16] Taipei Vet Gen Hosp, Taipei, Taiwan

[17] Tan Tock Seng Hosp, Singapore, Singapore

[18] HIV NAT Thai Red Cross AIDS Res Ctr, Bangkok, Thailand

[19] Mahidol Univ, Fac Med Ramathibodi Hosp, Bangkok, Thailand

[20] Res Inst Hlth Sci, Chiang Mai, Thailand

[21] Chiangrai Prachanukroh Hosp, Chiang Rai, Thailand

[22] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok, Thailand

[23] Natl Hosp Trop Dis, Hanoi, Vietnam

[24] Bach Mai Hosp, Hanoi, Vietnam

[25] AmfAR Fdn AIDS Res, TREAT Asia, Bangkok, Thailand

[26] UNSW Australia, Kirby Inst, Sydney, NSW, Australia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2016年 / 32卷 / 08期

基金：

美国国家卫生研究院;

关键词：

FOLLOW-UP; IMMUNOLOGICAL RESPONSE; PACIFIC REGION; THERAPY; OUTCOMES; CARE; INITIATION; MORTALITY; ADHERENCE; DISEASE;

D O I：

10.1089/aid.2015.0294

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asian countries have seen the expansion of combination antiretroviral therapy (cART) over the past decade. The TREAT Asia HIV Observational Database (TAHOD) was established in 2003 comprising 23 urban referral sites in 13 countries across the region. We examined trends in treatment outcomes in patients who initiated cART between 2003 and 2013. Time of cART initiation was grouped into three periods: 2003-2005, 20062009, and 2010-2013. We analyzed trends in undetectable viral load (VL; defined as VL <400 copies/ml), CD4 changes from pre-cART levels, and overall survival. Of 6,521 patients included, the overall median CD4 count at cART initiation was 120 cells/mu l (interquartile range: 38-218). Despite an increase over time, pre-cART CD4 counts remained < 200 cells/mu l. Adjusted analyses showed undetectable VL was more likely when starting cART in later years [2006-2009: odds ratio (OR) = 1.76, 95% confidence interval (CI) (1.45, 2.15); and 2010-2013: OR=3.04, 95% CI (2.33, 3.97), all p < .001, compared to 2003-2005], and survival was improved [2006-2009: subdistribution hazard ratio (SHR) = 0.41, 95% CI (0.27, 0.61), 2010-2013: SHR = 0.29, 95% CI (0.17, 0.49), all p < .001, compared to 2003-2005]. No differences in CD4 response was observed over time. Age and CD4 levels prior to cART initiation were associated with all three treatment outcomes, with older age and higher CD4 counts being associated with undetectable VL. Survival and VL response on cART have improved over the past decade in TAHOD, although CD4 count at cART initiation remained low. Greater effort should be made to facilitate earlier HIV diagnosis and linkage to care and treatment, to achieve greater improvements in treatment outcomes.

引用

页码：772 / 781

页数：10

共 50 条

[41] Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database
Zhou, J.
Paton, N. I.
Ditangco, R.
Chen, Y-Ma
Kamarulzaman, A.
Kumarasamy, N.
Lee, C. K. C.
Li, P. C. K.
Merati, T. P.
Phanuphak, P.
Pujari, S.
Vibhagool, A.
Zhang, F.
Chuah, J.
Frost, K. R.
Cooper, D. A.
Law, M. G.
HIV MEDICINE, 2007, 8 (01) : 8 - 16
[42] Prevalence, Characteristics, Management, and Outcome of Pulmonary Tuberculosis in HIV-Infected Children in the TREAT Asia Pediatric HIV Observational Database (TApHOD)
Sudjaritruk, Tavitiya
Maleesatharn, Alan
Prasitsuebsai, Wasana
Fong, Siew Moy
Ngoc Oanh Le
Thanh Thuy Thi Le
Lumbiganon, Pagakrong
Kumarasamy, Nagalingeswaran
Kurniati, Nia
Hansudewechakul, Rawiwan
Yusoff, Nik Khairulddin Nik
Razali, Kamarul Azahar Mohd
Kariminia, Azar
Sohn, Annette H.
Sirisanthana, Virat
AIDS PATIENT CARE AND STDS, 2013, 27 (12) : 649 - 656
[43] Cardiovascular disease-related mortality and factors associated with cardiovascular events in the TREAT Asia HIV Observational Database (TAHOD)
Bijker, R.
Jiamsakul, A.
Uy, E.
Kumarasamy, N.
Ditango, R.
Chaiwarith, R.
Wong, W. W.
Avihingsanon, A.
Sun, L. P.
Yunihastuti, E.
Pujari, S.
Do, C. D.
Merati, T. P.
Kantipong, P.
Nguyen, K. V.
Kamarulzaman, A.
Zhang, F.
Lee, M. P.
Choi, J. Y.
Tanuma, J.
Ng, O. T.
Sim, B. L. H.
Ross, J.
Kiertiburanakul, S.
Ly, P. S.
Khol, V.
Zhang, F. J.
Zhao, H. X.
Han, N.
Li, P. C. K.
Lam, W.
Chan, Y. T.
Saghayam, S.
Ezhilarasi, C.
Joshi, K.
Gaikwad, S.
Chitalikar, A.
Wirawan, D. N.
Yuliana, F.
Imran, D.
Widhani, A.
Oka, S.
Nishijima, T.
Na, S.
Kim, J. M.
Gani, Y. M.
David, R.
Omar, S. F. Syed
Ponnampalavanar, S.
Azwa, I.
HIV MEDICINE, 2019, 20 (03) : 183 - 191
[44] Predicting short-term disease progression among HIV-infected patients in Asia and the Pacific region: preliminary results from the TREAT Asia HIV Observational Database (TAHOD)
Zhou, J
Kumarasamy, N
HIV MEDICINE, 2005, 6 (03) : 216 - 223
[45] AIDS-defining illness diagnosed within 90 days after starting highly active antiretroviral therapy among patients from the TREAT Asia HIV Observational Database
Zhou, J.
Paton, N. I.
Ditangco, R.
INTERNATIONAL JOURNAL OF STD & AIDS, 2007, 18 (07) : 446 - 452
[46] Hepatitis B and C Co-Infection in HIV Patients from the TREAT Asia HIV Observational Database: Analysis of Risk Factors and Survival
Chen, Marcelo
Wong, Wing-Wai
Law, Matthew G.
Kiertiburanakul, Sasisopin
Yunihastuti, Evy
Merati, Tuti Parwati
Poh Lian Lim
Chaiwarith, Romanee
Phanuphak, Praphan
Lee, Man Po
Kumarasamy, Nagalingeswaran
Saphonn, Vonthanak
Ditangco, Rossana
Sim, Benedict L. H.
Kinh Van Nguyen
Pujari, Sanjay
Kamarulzaman, Adeeba
Zhang, Fujie
Thuy Thanh Pham
Choi, Jun Yong
Oka, Shinichi
Kantipong, Pacharee
Mustafa, Mahiran
Ratanasuwan, Winai
Durier, Nicolas
Chen, Yi-Ming Arthur
PLOS ONE, 2016, 11 (03):
[47] Impact of Antiretroviral Therapy on Opportunistic Infections of HIV-infected Children in the Therapeutic Research, Education and AIDS Training Asia Pediatric HIV Observational Database
Prasitsuebsai, Wasana
Kariminia, Azar
Puthanakit, Thanyawee
Lumbiganon, Pagakrong
Hansudewechakul, Rawiwan
Moy, Fong Siew
Law, Matthew
Kumarasamy, Nagalingeswaran
Razali, Kamarul
Sirisanthana, Virat
Sohn, Annette H.
Chokephaibulkit, Kulkanya
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2014, 33 (07) : 747 - 752
[48] The changing characteristics of a cohort of children and adolescents living with HIV at antiretroviral therapy initiation in Asia
Sornillo, Johanna Beulah
Ditangco, Rossana
Kinikar, Aarti
Wati, Dewi Kumara
Du, Quy Tuan
Nguyen, Dinh Qui
Khol, Vohith
Nguyen, Lam Van
Puthanakit, Thanyawee
Ounchanum, Pradthana
Kurniati, Nia
Chokephaibulkit, Kulkanya
Jamal Mohamed, Thahira A.
Sudjaritruk, Tavitiya
Fong, Siew Moy
Kumarasamy, Nagalingeswaran
Kosalaraksa, Pope
Nallusamy, Revathy A.
Nik Yusoff, Nik Khairulddin
Sohn, Annette H.
Kariminia, Azar
PLOS ONE, 2023, 18 (09):
[49] Diabetes, mortality and glucose monitoring rates in the TREAT Asia HIV Observational Database Low Intensity Transfer (TAHOD-LITE) study
Bijker, R.
Kumarasamy, N.
Kiertiburanakul, S.
Pujari, S.
Sun, L. Penh
Ng, O. T.
Lee, M. P.
Choi, J. Y.
Nguyen, K. V.
Chan, Y. J.
Merati, T. P.
Do, C. D.
Ross, J.
Law, M.
Ly, P. S.
Khol, V.
Lee, M. P.
Li, P. C. K.
Lam, W.
Chan, Y. T.
Kumarasamy, N.
Saghayam, S.
Ezhilarasi, C.
Pujari, S.
Joshi, K.
Gaikwad, S.
Chitalikar, A.
Merati, T. P.
Wirawan, D. N.
Yuliana, F.
Ng, O. T.
Lim, P. L.
Lee, L. S.
Ferdous, Z.
Choi, J. Y.
Na, S.
Kim, J. M.
Wong, W. W.
Ku, W. W.
Wu, P. C.
Do, C. D.
Ngo, A. V.
Nguyen, L. T.
Nguyen, K. V.
Bui, H. V.
Nguyen, D. T. H.
Nguyen, D. T.
Sohn, A. H.
Ross, J. L.
Petersen, B.
HIV MEDICINE, 2019, 20 (09) : 615 - 623
[50] Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database
Lim, Poh-Lian
Zhou, Jialun
Ditangco, Rossana A.
Law, Matthew G.
Sirisanthana, Thira
Kumarasamy, Nagalingeswaran
Chen, Yi-Ming A.
Phanuphak, Praphan
Lee, Christopher K. C.
Saphonn, Vonthanak
Oka, Shinichi
Zhang, Fujie
Choi, Jun Y.
Pujari, Sanjay
Kamarulzaman, Adeeba
Li, Patrick C. K.
Merati, Tuti P.
Yunihastuti, Evy
Messerschmidt, Liesl
Sungkanuparph, Somnuek
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2012, 15

← 1 2 3 4 5 →