Immunodeficiencies caused by genetic defects in protein kinases

被引：15

作者：

Notarangelo, LD

机构：

[1] Department of Pediatrics, University of Brescia, Brescia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(96)80028-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recognition that defects of ZAP-70 and, more recently, of JAK3 kinase in humans result in severe combined immunodeficiency, and the demonstration that targeting of these and other protein-kinase genes in mice also leads to immunodeficiency, have highlighted the crucial role that these proteins play in T-cell differentiation and activation.

引用

页码：448 / 453

页数：6

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