Arsenic induces Th1/Th2 imbalance in immune and non-immune organs

被引：0
|
作者：
Guo, Y. Y. [1 ]
Zhao, L. [1 ]
Yang, S. [1 ]
Sun, G. F. [1 ]
Li, B. [1 ]
Duan, X. X. [2 ]
Li, J. L. [3 ]
机构：
[1] China Med Univ, Sch Publ Hlth, Environm & Noncommunicable Dis Res Ctr, Key Lab Arsenicrelated Biol Effects & Prevent & T, Shenyang, Peoples R China
[2] Shenyang Med Coll, Sch Publ Hlth, Dept Toxicol, Shenyang, Liaoning, Peoples R China
[3] North China Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Key Lab Occupat Hlth & Safety Coal Ind Hebei Prov, Tangshan, Hebei, Peoples R China
来源：
ENVIRONMENTAL ARSENIC IN A CHANGING WORLD (AS2018) | 2018年
关键词：
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
CD4+ T helper (Th) cells, especially well balanced Th1/Th2 responses, are essential regulators of the immune responses and inflammatory diseases. Arsenic is a known immunosuppressive metalloid, but its detailed effects on immune and non-immune organs are poorly understood. In the present study, mice were treated with 2.5, 5 and 10 mg kg(-1) NaAsO2 intra-gastrically for 24 h. We found that arsenic exposure led to the persistent aberration of the inherent capability of Th cells to differentiate into Th1 and Th2 cells. These results might provide novel therapeutic strategies on arsenic-induced immune related diseases.
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页码：322 / 323
页数：2
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