Synthesis of 3-halo-2,5-disubstituted furans via CuX mediated cyclization-halogenation reactions

被引：4

作者：

Yazici, Arife ^{[1
]}

Pyne, Stephen G. ^{[1
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 12期

基金：

澳大利亚研究理事会;

关键词：

Cyclization-halogenation; Cyclization-cyanation; Cu(I) salts; 2,3,5-Trisubstituted furans;

D O I：

10.1016/j.tetlet.2011.01.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Cu(I) halide (X = I, Br, Cl) mediated reactions of Cbz-protected cis-2-phenylethenyl-3-hydroxypyrrolidine gave novel 3-halo-2,5-trisubstituted furans in good yields, via a cyclization-halogenation, ring-opening reaction sequence. In contrast, the reactions with CuCN gave mainly the corresponding 3-cyanofuro[3,2-b]pyrrole formed from a cyclization-cyanation reaction. (C) 2011 Published by Elsevier Ltd.

引用

页码：1398 / 1400

页数：3

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