Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome

被引:18
|
作者
Wang, Siyu [1 ,2 ,3 ]
Mu, Liangshan [1 ,4 ]
Zhang, Chunmei [1 ,4 ]
Long, Xiaoyu [1 ,4 ]
Zhang, Yurong [1 ,2 ,3 ]
Li, Rong [1 ,2 ,3 ,4 ]
Zhao, Yue [1 ,2 ,3 ,4 ,5 ]
Qiao, Jie [1 ,2 ,3 ,4 ,5 ]
机构
[1] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
[2] Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
[3] Beijing Key Lab Reprod Endocrinol & Assisted Repro, Beijing, Peoples R China
[4] Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Res Units Comprehens Diag & Treatment Oocyte Matur, Beijing, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
polycystic ovary syndrome; tryptophan metabolism; kynurenine; kynurenic acid; obesity; INDOLEAMINE 2,3-DIOXYGENASE; QUINOLINIC ACID; METABOLISM; DYSREGULATION; ASSOCIATION; DIAGNOSIS; CRITERIA; OBESITY; CELLS;
D O I
10.3389/fendo.2022.877807
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS. However, the changes of downstream metabolites in tryptophan catabolism pathways remain unclear. MethodsThis is a cross-sectional study that included 200 PCOS patients and 200 control women who were recruited from the Reproductive Medicine Center of Peking University Third Hospital from October 2017 to June 2019. The PCOS patients and the control group were further divided into subtypes of normal weight and overweight/obesity. Fasting blood samples from all subjects were collected on days 2~3 of a natural menstrual cycle or when amenorrhea for over 40 days with follicle diameter not exceeding 10 mm. The plasma levels of tryptophan metabolites were quantitatively determined by the liquid chromatograph mass spectrometer, including tryptophan, serotonin, kynurenine, kynurenic acid, 3-hydroxykynurenine, and quinolinic acid. ResultsThe tryptophan-kynurenine pathway was dysregulated in women with PCOS, along with significantly elevated levels of tryptophan, serotonin, kynurenine, kynurenic acid, and quinolinic acid. Moreover, levels of tryptophan, kynurenine, and kynurenic acid were positively correlated with luteinizing hormone, anti-Mullerian hormone, fasting insulin, HOMA-IR. tryptophan, and kynurenine and quinolinic acid had an obvious association with C-reactive protein levels. Furthermore, logistic regression showed that tryptophan, serotonin, kynurenine, kynurenic acid and quinolinic acid were all associated significantly with the increased risk of PCOS with the adjustment for potential confounding factors. Additionally, tryptophan, kynurenine, and kynurenic acid had good diagnostic performances for PCOS, and their combination exhibited higher sensitivity and specificity to diagnostic efficiency, with the area under the ROC curve of 0.824 (95% CI 0.777-0.871), which was comparable to the endocrine indicators. Conclusion (s)The tryptophan-kynurenine pathway was abnormally activated in PCOS patients.
引用
收藏
页数:10
相关论文
共 50 条
  • [31] An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway
    Jamshed, Laiba
    Debnath, Amrita
    Jamshed, Shanza
    Wish, Jade, V
    Raine, Jason C.
    Tomy, Gregg T.
    Thomas, Philippe J.
    Holloway, Alison C.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)
  • [32] Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
    Ping Song
    Tharmarajan Ramprasath
    Huan Wang
    Ming-Hui Zou
    Cellular and Molecular Life Sciences, 2017, 74 : 2899 - 2916
  • [33] Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
    Song, Ping
    Ramprasath, Tharmarajan
    Wang, Huan
    Zou, Ming-Hui
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (16) : 2899 - 2916
  • [34] Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery
    Christensen, Monika H. E.
    Fadnes, Dag J.
    Rost, Therese H.
    Pedersen, Eva R.
    Andersen, John R.
    Vage, Villy
    Ulvik, Arve
    Midttun, Oivind
    Ueland, Per M.
    Nygard, Ottar K.
    Mellgren, Gunnar
    PLOS ONE, 2018, 13 (02):
  • [35] Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression
    Laugeray, Anthony
    Launay, Jean-Marie
    Callebert, Jacques
    Surget, Alexandre
    Belzung, Catherine
    Barone, Pascal R.
    BEHAVIOURAL BRAIN RESEARCH, 2010, 210 (01) : 84 - 91
  • [36] Predictive markers for abnormal glucose intolerance in women with polycystic ovary syndrome
    Jeong, Kyungah
    Park, So Yun
    Jeon, Ji Hyun
    Lee, Sa Ra
    Chung, Hye Won
    MINERVA MEDICA, 2016, 107 (04) : 185 - 193
  • [37] Fatigue or Tolerance-Induction in Primary Sjogren's Syndrome: A Detrimental or Beneficial Role for IDO and the Tryptophan-Kynurenine Pathway?
    Maria, Naomi I.
    van Helden-Meeuwsen, C. G.
    Brkic, Z.
    Paulissen, S. M. J.
    Dalm, V. A.
    van Daele, P. L.
    van Hagen, P. M.
    Gibney, S. M.
    Harkin, A.
    Drexhage, H. A.
    Lubberts, E.
    Versnel, M. A.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2015, 81 (05) : 393 - 393
  • [38] Tobacco induces abnormal metabolism of tryptophan via the kynurenine pathway
    Onmaz, Mustafa
    Onmaz, Duygu Eryavuz
    Demirbas, Nur
    Kutlu, Ruhusen
    Unlu, Ali
    Hatir, Ahmet Emre
    TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2025, 50 (01): : 152 - 159
  • [39] Activation of mtor signaling pathway associated with polycystic ovary syndrome (PCOS)
    Yaba, A.
    Demir, N.
    HUMAN REPRODUCTION, 2011, 26 : I298 - I298
  • [40] Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis
    Claria, Joan
    Moreau, Richard
    Fenaille, Francois
    Amoros, Alex
    Junot, Christophe
    Gronbaek, Henning
    Coenraad, Minneke J.
    Pruvost, Alain
    Ghettas, Aurelie
    Chu-Van, Emeline
    Lopez-Vicario, Cristina
    Oettl, Karl
    Caraceni, Paolo
    Alessandria, Carlo
    Trebicka, Jonel
    Pavesi, Marco
    Deulofeu, Carme
    Albillos, Agustin
    Gustot, Thierry
    Welzel, Tania M.
    Fernandez, Javier
    Stauber, Rudolf E.
    Saliba, Faouzi
    Butin, Noemie
    Colsch, Benoit
    Moreno, Christophe
    Durand, Francois
    Nevens, Frederik
    Banares, Rafael
    Benten, Daniel
    Gines, Pere
    Gerbes, Alexander
    Jalan, Rajiv
    Angeli, Paolo
    Bernardi, Mauro
    Arroyo, Vicente
    HEPATOLOGY, 2019, 69 (04) : 1686 - 1701