Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

被引：11
|
作者：
Vance, David J. [1 ]
Rong, Yinghui [1 ]
Brey, Robert N., III [2 ]
Mantis, Nicholas J. [1 ,3 ]
机构：
[1] New York State Dept Hlth, Wadsworth Ctr, Div Infect Dis, Albany, NY USA
[2] Soligenix Inc, Princeton, NJ USA
[3] SUNY Albany, Dept Biomed Sci, Albany, NY USA
来源：
VACCINE | 2015年 / 33卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Toxin; Biodefense; Vaccine; Antigen; IMMUNOGENICITY; DEAMIDATION; ANTIBODIES; TRIAL;
D O I：
10.1016/j.vaccine.2014.11.036
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：417 / 421
页数：5
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