Serum CYFRA21-1 as a prognostic marker for patients with undifferentiated nasopharyngeal carcinoma

被引：20
|
作者：
Zhu, Wan-Qi [1 ]
Yu, Jin-Ming [1 ]
Sun, Xin-Dong [1 ]
Xie, Peng [1 ]
Kong, Li [1 ]
机构：
[1] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China
来源：
BIOMARKERS | 2010年 / 15卷 / 07期
关键词：
Nasopharyngeal carcinoma; undifferentiated; CYFRA21-1; CEA; prognosis; SQUAMOUS-CELL CARCINOMA; TUMOR-MARKERS; LUNG-CANCER; STAGE-I; HEAD; NECK; EXPRESSION; CYFRA-21-1; ANTIGEN; ADENOCARCINOMA;
D O I：
10.3109/1354750X.2010.504309
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The purpose of this study was to evaluate the potential of serum CYFRA21-1 and carcinoembryonic antigen (CEA) as prognostic markers in patients with undifferentiated nasopharyngeal carcinoma. Sixty-one patients who received definitive radiotherapy/chemoradiotherapy were analysed retrospectively. We investigated the association of the follow-up results with pretreatment level, post-treatment level and change of serum CYFRA21-1 and CEA, respectively. Patients with low pretreatment CYFRA21-1 had a significantly better overall survival. There were no significant associations among the remaining serum markers, and the survival and recurrence rates on multivariate analysis. The present study shows that pretreatment CYFRA21-1 level is a potential factor for predicting long-term survival.
引用
收藏
页码：602 / 607
页数：6
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