Serum CYFRA21-1 as a prognostic marker for patients with undifferentiated nasopharyngeal carcinoma

被引：20

作者：

Zhu, Wan-Qi ^{[1
]}

Yu, Jin-Ming ^{[1
]}

Sun, Xin-Dong ^{[1
]}

Xie, Peng ^{[1
]}

Kong, Li ^{[1
]}

机构：

[1] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China

来源：

BIOMARKERS | 2010年 / 15卷 / 07期

关键词：

Nasopharyngeal carcinoma; undifferentiated; CYFRA21-1; CEA; prognosis; SQUAMOUS-CELL CARCINOMA; TUMOR-MARKERS; LUNG-CANCER; STAGE-I; HEAD; NECK; EXPRESSION; CYFRA-21-1; ANTIGEN; ADENOCARCINOMA;

D O I：

10.3109/1354750X.2010.504309

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The purpose of this study was to evaluate the potential of serum CYFRA21-1 and carcinoembryonic antigen (CEA) as prognostic markers in patients with undifferentiated nasopharyngeal carcinoma. Sixty-one patients who received definitive radiotherapy/chemoradiotherapy were analysed retrospectively. We investigated the association of the follow-up results with pretreatment level, post-treatment level and change of serum CYFRA21-1 and CEA, respectively. Patients with low pretreatment CYFRA21-1 had a significantly better overall survival. There were no significant associations among the remaining serum markers, and the survival and recurrence rates on multivariate analysis. The present study shows that pretreatment CYFRA21-1 level is a potential factor for predicting long-term survival.

引用

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页码：602 / 607

页数：6

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