Plants as a source of anti-cancer and anti-HIV agents

被引：55
|
作者：
Cragg, GM [1 ]
Newman, DJ [1 ]
机构：
[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis, Ft Detrick, MD 21702 USA
来源：
ANNALS OF APPLIED BIOLOGY | 2003年 / 143卷 / 02期
关键词：
AIDS; cancer; drugs; HIV; plant products;
D O I：
10.1111/j.1744-7348.2003.tb00278.x
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, and paclitaxel (Taxol(R)). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and Combretastatin A4 phosphate. Recently, plants have yielded several agents showing anti-AIDS activity, and one of these, (+)-calanolide A, is in clinical development.
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页码：127 / 133
页数：7
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