Improved preparation of nabumetone by Raney Ni catalytic hydrogenation

被引：1
|
作者：
Yang, Fan [2 ]
Wang, Lixin [1 ]
Li, Xianguo [1 ]
Shen, Jianfen [1 ]
Wang, Jiyu [1 ]
Yu, Xiaoqi [2 ]
机构：
[1] Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Dept Chem, Chengdu 610041, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 03期
关键词：
D O I：
10.2174/157017808783955826
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nabumetone is efficiently and economically prepared from hydrogenation of 3-methoxycarbonyl-4-(6-methoxy-2-naphthyl) but-3-en-2-one catalyzed by Raney Ni (W-2) under 145.0 psi H-2 at 45 degrees C and subsequent acid hydrolysis in 88.1% yield and 99% purity (GC). A high vacuum distillation or rectification purification method is used to improve the whole qualification of nabumetone.
引用
收藏
页码：191 / 193
页数：3
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