Improved preparation of nabumetone by Raney Ni catalytic hydrogenation

被引：1
|
作者：
Yang, Fan [2 ]
Wang, Lixin [1 ]
Li, Xianguo [1 ]
Shen, Jianfen [1 ]
Wang, Jiyu [1 ]
Yu, Xiaoqi [2 ]
机构：
[1] Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Dept Chem, Chengdu 610041, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 03期
关键词：
D O I：
10.2174/157017808783955826
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nabumetone is efficiently and economically prepared from hydrogenation of 3-methoxycarbonyl-4-(6-methoxy-2-naphthyl) but-3-en-2-one catalyzed by Raney Ni (W-2) under 145.0 psi H-2 at 45 degrees C and subsequent acid hydrolysis in 88.1% yield and 99% purity (GC). A high vacuum distillation or rectification purification method is used to improve the whole qualification of nabumetone.
引用
收藏
页码：191 / 193
页数：3
相关论文
共 50 条
  • [1] Preparation of Raney Ni by ultrasonic wave and its catalytic activity in benzene hydrogenation
    Meng, Q
    Wu, YD
    Wan, Y
    Li, HX
    CHINESE JOURNAL OF CATALYSIS, 2004, 25 (07) : 529 - 532
  • [2] Metal fluoride promoted catalytic hydrogenation of aromatic nitro compounds over RANEY® Ni
    Liu, Xia
    Ma, Xuanxuan
    Liu, Sujing
    Liu, Ying
    Xia, Chuanhai
    RSC ADVANCES, 2015, 5 (46): : 36423 - 36427
  • [3] High temperature catalytic hydrogenation of acetone over Raney Ni for chemical heat pump
    Yanjun Duan
    Min Xu
    Xiulan Huai
    Journal of Thermal Science, 2014, 23 : 85 - 90
  • [4] High Temperature Catalytic Hydrogenation of Acetone over Raney Ni for Chemical Heat Pump
    Duan Yanjun
    Xu Min
    Huai Xiulan
    JOURNAL OF THERMAL SCIENCE, 2014, 23 (01) : 85 - 90
  • [5] High Temperature Catalytic Hydrogenation of Acetone over Raney Ni for Chemical Heat Pump
    DUAN Yanjun
    XU Min
    HUAI Xiulan
    JournalofThermalScience, 2014, 23 (01) : 85 - 90
  • [6] Study on catalytic hydrogenation of rosin on Raney nickel
    Chen, Xiao-Peng
    Wang, Lin-Lin
    Ma, Jian
    Yang, Cheng-Li
    2002, Chemistry and Industry of Forest Products (22):
  • [7] THE CATALYTIC HYDROGENATION OF DIPHENYL IN THE PRESENCE OF RANEY NICKEL
    GOODMAN, I
    JOURNAL OF THE CHEMICAL SOCIETY, 1951, (JUN): : 1371 - 1372
  • [8] CATALYTIC HYDROGENATION OF ALDEHYDECOLLIDINE WITH RANEY CATALYSTS ACCOMPANIED BY ALKYLATION
    MARUOKA, M
    ISAGAWA, K
    FUSHIZAK.Y
    KUKI, T
    NIPPON KAGAKU ZASSHI, 1961, 82 (07): : 917 - &
  • [9] Metals Leaching Mechanism of Fe or/and Mo Modified Raney-Ni Catalysts and Their Catalytic Hydrogenation of Glucose
    Zhang Qunfeng
    Liu Wei
    Lu Chunshan
    Ma Lei
    Lu Jinghui
    Feng Feng
    Li Xiaonian
    RARE METAL MATERIALS AND ENGINEERING, 2012, 41 : 514 - 519
  • [10] HYDROGENATION OF DEHYDROINALOOL OVER RANEY NI AND PD CATALYSTS
    PAK, AM
    SOKOLSKII, DV
    KARTONOZHKINA, OI
    VYAZNIKOVTSEVA, OV
    LITVYAKOVA, EN
    JOURNAL OF APPLIED CHEMISTRY OF THE USSR, 1980, 53 (09): : 1526 - 1529
12345