Hypertension in spontaneously hypertensive rats occurs despite low plasma levels of homocysteine

被引:9
|
作者
Kondziella, D. [1 ,5 ]
Zetterberg, H. [2 ]
Haugen, E. [3 ]
Fu, M. [4 ]
机构
[1] Gothenburg Univ, Hosp Sahlgrenska, Dept Neurol, SE-41345 Gothenburg, Sweden
[2] Gothenburg Univ, Hosp Sahlgrenska, Dept Clin Neurochem, SE-41345 Gothenburg, Sweden
[3] Gothenburg Univ, Hosp Sahlgrenska, Dept Cardiol, SE-41345 Gothenburg, Sweden
[4] Gothenburg Univ, Hosp Sahlgrenska, Dept Internal Med, SE-41345 Gothenburg, Sweden
[5] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway
关键词
amino acids; arginine; citrulline; homocysteine; hypertension; ion exchange chromatography; nitric oxide; ornithine; spontaneously hypertensive rats (SHR);
D O I
10.33549/physiolres.931189
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Hyperhomocysteinemia has been suggested to induce hypertension due to its role in endothelial dysfunction. However, it remains controversial whether homocysteine and hypertension are truly causally related or merely loosely associated. To test the hypothesis that hyperhomocysteinemia occurs in spontaneously hypertensive rats (SHR) we measured plasma levels of homocysteine in 10 male adult SHR and in 10 normotensive controls using ion exchange chromatography. In addition, plasma concentrations of the 22 most common amino acids were measured to explore the relation of homocysteine with amino acid metabolism. Plasma levels of homocysteine were significantly lower in SHR (4.1 +/- 0.1 mu mol/l) than in controls (7.2 +/- 0.3 mu mol/l) ( p < 0.00001). The amounts of aminobutyric acid, alanine, citrulline and valine were also decreased, whereas we found increased levels of aspartate, glutamate, glutamine, histidine and ornithine. Thus, contrary to our hypothesis, hypertension in SHR occurs despite low plasma levels of homocysteine. We provide a new hypothesis whereby reduced conversion of arginine to citrulline is related to increased ornithine levels, but decreased bioavailability of nitric oxide, resulting in impaired blood vessel relaxation and hypertension. In conclusion, our findings do not necessarily exclude that homocysteine and hypertension might be pathophysiologically connected, but corroborate the notion that hypertension can arise due to mechanisms independent of high homocysteine levels.
引用
收藏
页码:487 / 490
页数:4
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