Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

被引：14

作者：

Srivastav, Naveen C. ^{[1
]}

Shakya, Neeraj ^{[1
]}

Bhavanam, Sudha ^{[1
]}

Agrawal, Amogh ^{[1
]}

Tse, Chris ^{[1
]}

Desroches, Nancy ^{[1
]}

Kunimoto, Dennis Y. ^{[2
]}

Kumar, Rakesh ^{[1
]}

机构：

[1] Univ Alberta Hosp, Dept Lab Med & Pathol, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Fac Med & Dent, Dept Med, Edmonton, AB T6G 2H7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 02期

基金：

加拿大健康研究院;

关键词：

Tuberculosis; Pyrimidine nucleosides; MYCOBACTERIUM-TUBERCULOSIS; ANTIVIRAL ACTIVITY; RESISTANT; BOVIS; DEOXYRIBONUCLEOSIDES; 3'-AZIDO; STRAINS; HIV-1;

D O I：

10.1016/j.bmcl.2011.11.114

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC50 = 1 mu g/mL), M. tuberculosis (MIC50 = 10 mu g/mL) and M. avium (MIC50 = 10 mu g/mL). (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1091 / 1094

页数：4

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