The bactericidal activity of clarithromycin versus ampicillin alone and in combination with omeprazole and/or bismuth against clarithromycin-susceptible and. Clarithromycin-resistant strains of Helicobacter pylori

被引：2
|
作者：
Coudron, PE [1 ]
Stratton, CW [1 ]
机构：
[1] McGuire Dept Vet Affairs Med Ctr, Pathol & Lab Med Serv 113, Richmond, VA 23249 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1998年 / 32卷 / 01期
关键词：
D O I：
10.1016/S0732-8893(98)00054-6
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We evaluated the in vitro bactericidal effect of clarithromycin versus ampicillin alone and in combination against clarithromycin-sensitive and clarithromycin-resistant strains of Helicobacter pylori. No combination containing clarithromycin achieved complete bactericidal effect against clarithromycin-resistant strains. Complete bactericidal effect ions achieved for all strains by triple-agent combinations that contained bismuth, omeprazole, and relatively high concentrations of ampicillin. These in vitro results demonstrate the additive bactericidal activity provided by a combination of agents for the eradication of H, pylori. Bismuth may play a particularly important role in the bactericidal effect. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：39 / 44
页数：6
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