Superoxide scavenging activities of sixty Chinese medicines determined by an ESR spin-trapping method using electrogenerated superoxide

被引：16

作者：

Liu, WW

Ogata, T ^{[1
]}

Sato, S

Unoura, K

Onodera, J

机构：

[1] Yamagata Univ, Grad Sch Sci & Engn, Yonezawa, Yamagata 9928510, Japan

[2] Yamagata Univ, Fac Sci, Dept Mat & Biol Chem, Yamagata 9908560, Japan

[3] Yamagata Univ, Fac Engn, Dept Chem & Chem Engn, Yonezawa, Yamagata 9928510, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2001年 / 121卷 / 04期

关键词：

Chinese medicines; superoxide; scavenging activity; ESR; electrolysis of oxygen;

D O I：

10.1248/yakushi.121.265

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Superoxide-scavenging activities of 60 kinds of Chinese herbal medicines were determined accurately by an electron spin resonance (ESR) spin-trapping technique using 5,5-dimethyl-1-pyrroline 1-oxide (DMPO), as a spin-trapping reagent. As a source of superoxide in this method, superoxide generated by one-electron reduction of the oxygen molecule in dimethyl sulfoxide solution was used. As a result of these studies, very powerful scavenging activity was found in Chinese medicines for inflammation, diseases of blood circulation and for tumors.

引用

页码：265 / 270

页数：6

共 23 条

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