miRNAs as biomarkers for management of patients with colorectal cancer

被引：29

作者：

Manne, Upender ^{[1
,2
]}

Shanmugam, Chandrakumar ^{[1
]}

Bovell, Liselle ^{[1
]}

Katkoori, Venkat R. ^{[1
]}

Bumpers, Harvey L. ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA

[3] Morehouse Sch Med, Dept Surg, Atlanta, GA 30310 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 05期

关键词：

biomarker; colorectal cancer; diagnosis; miRNA; prognosis; therapeutic target; IN-SITU DETECTION; MICRORNA EXPRESSION; TUMOR-SUPPRESSOR; GENE-EXPRESSION; DOWN-REGULATION; OVARIAN-CANCER; COLON; RNA; GROWTH; MIR-34A;

D O I：

10.2217/BMM.10.87

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

miRNAs serve as micromanagers, negatively regulating gene expression. Since altered miRNA expression is implicated in the pathobiology of various cancers, including colorectal cancers (CRCs), these molecules serve as potential therapeutic targets. Manipulation of miRNAs may offer an alternative therapy for chemo- and radio-resistant CRCs. For CRC patients, miRNA expression patterns can be used for diagnosis, and to predict prognosis and efficacy of therapy. This article describes the methodological approaches for miRNA measurement, their function in the pathobiology of CRCs and their potential clinical utility.

引用

页码：761 / 770

页数：10

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