Toxins of Bacillus anthracis

被引：101
|
作者：
Brossier, F [1 ]
Mock, M [1 ]
机构：
[1] Inst Pasteur, CNRS, URA 2172, Unite Toxines & Pathogenie Bacteriennes, F-75725 Paris 15, France
来源：
TOXICON | 2001年 / 39卷 / 11期
关键词：
Bacillus anthracis; toxins; pathogenesis; immunoprotection;
D O I：
10.1016/S0041-0101(01)00161-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subit death in animals, the edema toxin (PA + EF) induces edema. The edema and the lethal factors are internalised into the eukaryotic target cells via the protective antigen. EF and LF exert a calmoduline dependent adenylate cyclase and a metalloprotease activity respectively. Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed. (C) 2001 Published by Elsevier Science Ltd.
引用
收藏
页码：1747 / 1755
页数：9
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