A synthesis of (+)-ipalbidine using sulfur-controlled 6-exo selective radical cyclization of α-phenylthio amide

被引：20
|
作者：
Ikeda, M [1 ]
Shikaura, J
Maekawa, N
Daibuzono, K
Teranishi, H
Teraoka, Y
Oda, N
Ishibashi, H
机构：
[1] Kyoto Pharmaceut Univ, Kyoto 6078414, Japan
[2] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan
来源：
HETEROCYCLES | 1999年 / 50卷 / 01期
关键词：
D O I：
10.3987/COM-98-S(H)13
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthesis of (+/-)-ipalbidine (1) has been achieved using Bu3SnH-mediated 6-exo selective radical cyclization of 2-[3-(phenylthio)prop-2-enyl]-N-[alpha-(p-methoxyphenyl)-alpha-(phenylthio)acetyl]pyrrolidine (15) as a key step.
引用
收藏
页码：31 / 34
页数：4
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