Development of a 5-exo, 6-exo tandem radical cyclization to access bisabosqual A

被引：4
|
作者：
Ende, Christopher W. Am [1 ,2 ]
Parker, Kathlyn A. [1 ]
机构：
[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[2] Pfizer Worldwide Res & Dev, Eastern Point Rd, Groton, CT 06340 USA
来源：
TETRAHEDRON | 2019年 / 75卷 / 32期
基金：
美国国家卫生研究院;
关键词：
Tandem; Radical; Cyclization; Cascade; Photoredox; cis fused ring system; KETONES; ALKYL;
D O I：
10.1016/j.tet.2019.05.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substrates were designed to undergo tandem radical cyclizations to afford the cis, cis-fused hexahydrobenzofurobenzopyran ring system of the bisabosquals. Studies with these revealed that different initiating systems gave different yields and somewhat different diastereomeric ratios. A photocatalytic cyclization was also successful with the bisabosqual substrate. (C) 2019 Elsevier Ltd. All rights reserved.
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页码：4255 / 4260
页数：6
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