Expression of the α1D subunit of the L-type voltage gated calcium channel in human liver

被引：0
|
作者：
Okamoto, T
Jeong, SY
Takahashi, Y
Baughman, KW
Ogata, K
Goto, J
Kanazawa, I
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 3410005, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2001年 / 8卷 / 04期
关键词：
calcium channel; calcium channel blocker; hepatitis;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha -subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. For clinical application of calcium channel blocker, it is important to analyze the expression of the L-type calcium channel in the liver. However, the subtype of the L-type calcium channel alpha -subunit expressed in the liver was not known. In the present study, the alpha -subunit of the calcium channel expressed in human liver was systematically analyzed. The alpha 1D subunit of the dihydropyridine-sensitive L-type voltage gated calcium channel is expressed relatively strongly in the liver and may play an important role in the liver.
引用
收藏
页码：413 / 416
页数：4
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