Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair

被引：61
|
作者：
Liu, Chun [1 ]
Li, Yun [1 ]
Yang, Zhijian [2 ]
Zhou, Zhiyou [1 ]
Lou, Zhihao [1 ]
Zhang, Qiqing [1 ]
机构：
[1] Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Agr, Fuzhou 350002, Peoples R China
来源：
NANOMEDICINE | 2020年 / 15卷 / 03期
关键词：
bone marrow mesenchymal stem cells; chondrocytes; exosomes; kartogenin; osteoarthritis; OSTEOARTHRITIS; REGENERATION; CHONDROGENESIS; PROLIFERATION; ANGIOGENESIS; CHONDROCYTES; KNEE;
D O I：
10.2217/nnm-2019-0208
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effectiveness of mesenchymal stem cells (MSC) in the treatment of cartilage diseases has been demonstrated to be attributed to the paracrine mechanisms, especially the mediation of exosomes. But the exosomes derived from unsynchronized MSCs may be nonhomogeneous and the therapeutic effect varies between samples. Aim: To produce homogeneous and more effective exosomes for the regeneration of cartilage. Materials & methods: In this study we produced specific exosomes from bone marrow MSCs (BMSC) through kartogenin (KGN) preconditioning and investigated their performance in either in vitro or in vivo experiments. Results & conclusion: The exosomes derived from KGN-preconditioned BMSCs (KGN-BMSC-Exos) performed more effectively than the exosomes derived from BMSCs (BMSC-Exos). KGN preconditioning endowed BMSC-Exos with stronger chondral matrix formation and less degradation.
引用
收藏
页码：273 / 288
页数：16
相关论文
共 50 条
  • [31] Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow
    Tanimoto, K.
    Huang, Y. C.
    Tanne, Y.
    Kunimatsu, R.
    Michida, M.
    Yoshioka, M.
    Ozaki, N.
    Sasamoto, T.
    Yoshimi, Y.
    Kato, Y.
    Tanne, K.
    CELLS TISSUES ORGANS, 2012, 196 (05) : 411 - 419
  • [32] Therapeutic Effects of Human Bone Marrow Mesenchymal Stem Cells Derived Exosomes on Glucocorticoid-Induced Osteoporosis: In Vitro Model
    Eren, Simge
    Unsal, Naz
    Kabatas, Bilge
    Yildirim, Merve
    Eren, Olcay
    HORMONE RESEARCH IN PAEDIATRICS, 2024, 97 : 36 - 36
  • [33] Comparing the therapeutic influence of bone marrow Mesenchymal stem cells versus its derived exosomes against diabetic hepatopathy in rats
    Khereldin, Rehab Mahmoud
    Abouelela, Yara Sayed
    Yasin, Noha Ali Elsayed
    Youssef, Fady Sayed
    Abdelhameed, Marwa Ibrahim
    Tohamy, Adel Fathy
    Rizk, Hamdy
    Daghash, Samer Mohamed
    EXPERIMENTAL CELL RESEARCH, 2025, 447 (01)
  • [34] Effects of Cartilage Progenitor Cells, Bone Marrow Mesenchymal Stem Cells and Chondrocytes on Cartilage Repair as Seed Cells: An in vitro Study
    Gu, Jiaxiang
    Wang, Bin
    Wang, Tianliang
    Zhang, Naichen
    Liu, Hongjun
    Gui, Jianchao
    Lu, Yiming
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 1217 - 1230
  • [35] Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells
    Lujun Ji
    Liuliu Bao
    Zhifeng Gu
    Qiao Zhou
    Yi Liang
    Ya Zheng
    Yang Xu
    Xiang Zhang
    Xingmei Feng
    Immunologic Research, 2019, 67 : 432 - 442
  • [36] Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells
    Ji, Lujun
    Bao, Liuliu
    Gu, Zhifeng
    Zhou, Qiao
    Liang, Yi
    Zheng, Ya
    Xu, Yang
    Zhang, Xiang
    Feng, Xingmei
    IMMUNOLOGIC RESEARCH, 2019, 67 (4-5) : 432 - 442
  • [37] Notch pathway and matrix metalloproteinases in the repair of cartilage injury with bone marrow mesenchymal stem cells
    Gu, Wenqi
    Ma, Xin
    An, Ziquan
    Sun, Yuan
    Cheng, Xiangguo
    Gao, Youshui
    Hu, Bin
    Qian, Yebin
    Mao, Yanjie
    Wen, Gen
    Liu, Wanjun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (03): : 3251 - 3257
  • [38] Combining monocytes with mesenchymal stem cells for therapeutic cartilage repair
    Wardale, J.
    Mullen, L. M.
    Hopper, N. M.
    Ghose, S.
    Rushton, N.
    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2011, 92 (03) : A27 - A28
  • [39] Hypoxia Enhances Mesenchymal Characteristics Maintenance of Buffalo Bone Marrow-Derived Mesenchymal Stem Cells
    Zhang, Jun
    Lei, Chuan
    Deng, Yanfei
    Ahmed, Jam Zaheer
    Shi, Deshun
    Lu, Fenghua
    CELLULAR REPROGRAMMING, 2020, 22 (03) : 167 - 177
  • [40] Impaired Immunosuppressive Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on T Cells in Aplastic Anemia
    Wang, Shichong
    Huo, Jiali
    Liu, Yilin
    Chen, Lingyun
    Ren, Xiang
    Li, Xingxin
    Wang, Min
    Jin, Peng
    Huang, Jinbo
    Nie, Neng
    Zhang, Jing
    Shao, Yingqi
    Ge, Meili
    Mi, Yingchang
    Zheng, Yizhou
    BLOOD, 2023, 142
12345