The human T cell immune response to Epstein-Barr virus

被引:41
|
作者
Landais, E [1 ]
Saulquin, X [1 ]
Houssaint, E [1 ]
机构
[1] Inst Biol, INSERM, U463, F-44035 Nantes, France
来源
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2005年 / 49卷 / 2-3期
关键词
Epstein-Barr virus; T cell response; EBV-associated tumor;
D O I
10.1387/ijdb.041947el
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Epstein-Barr virus (EBV) is a gamma-herpes virus which establishes latent, lifelong infection in more than 95% of the human adult population. Despite its growth transforming capacity, most carriers control EBV associated malignacies efficiently and remain free of EBV+ tumors. Though EBV is controlled by a potent immune response, this virus uses latency to persist in vivo. This review summarizes work which has been done to characterize T cell responses to EBV. The CD8 T cell responses are rather well characterized and have been shown by several groups to be highly focused towards early lytic antigens. Much less is known about CD4 T cell epitopes, due to the small size of the CD4 compartment. However, recent data indicate a control of lytic and latent cycles of EBV by specific CD4+ T cells. A clear understanding of the T cell response to EBV is important with a view to developing immunotherapies for the virus and its related malignancies.
引用
收藏
页码:285 / 292
页数:8
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