Direct Thrombin Inhibitors

被引：15

作者：

O'Brien, P. Joshua ^{[1
]}

Mureebe, Leila ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Vasc Surg Sect, Durham, NC 27710 USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2012年 / 17卷 / 01期

关键词：

thrombosis; pathophysiology; TOTAL HIP-REPLACEMENT; ECARIN CLOTTING TIME; HEPARIN-INDUCED THROMBOCYTOPENIA; MOLECULAR-WEIGHT HEPARIN; DEEP-VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM; DABIGATRAN ETEXILATE; KNEE REPLACEMENT; DOUBLE-BLIND; ANTICOAGULANT-THERAPY;

D O I：

10.1177/1074248410395941

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having served humanity for nearly a century, are both inconvenient and nonspecific. Through both direct and indirect roles, thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis. This article will review the nature of direct thrombin inhibitors, current indications, and ongoing trials.

引用

页码：5 / 11

页数：7

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