Mixtures of environmentally relevant endocrine disrupting chemicals affect mammary gland development in female and male rats

被引：28
|
作者：
Mandrup, Karen Riiber [1 ]
Johansson, Hanna Katarina Lilith [1 ]
Boberg, Julie [1 ]
Pedersen, Anne Stilling [1 ]
Mortensen, Mette Sidsel [1 ]
Jorgensen, Jennifer Solgaard [1 ]
Vinggaard, Anne Marie [1 ]
Hass, Ulla [1 ]
机构：
[1] Tech Univ Denmark, Natl Food Inst, Div Toxicol & Risk Assessment, DK-2860 Soborg, Denmark
来源：
REPRODUCTIVE TOXICOLOGY | 2015年 / 54卷
基金：
欧盟第七框架计划;
关键词：
Endocrine disruption; Mammary gland; Mix; Oestrogens; Anti-androgens; Whole mount; Histology; Mmp; SEXUALLY IMMATURE RATS; SPRAGUE-DAWLEY RATS; IN-UTERO; ACETYLSALICYLIC-ACID; REPRODUCTIVE-SYSTEM; RECEPTOR ANTAGONIST; OLFACTORY RECEPTOR; GENISTEIN EXPOSURE; DIETARY GENISTEIN; BISPHENOL-A;
D O I：
10.1016/j.reprotox.2014.09.016
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Estrogenic chemicals are able to alter mammary gland development in female rodents, but little is known on the effects of anti-androgens and mixtures of endocrine disrupting chemicals (EDCs) with dissimilar modes of action. Pregnant rat dams were exposed during gestation and lactation to mixtures of environmentally relevant EDCs with estrogenic, anti-androgenic or dissimilar modes of action (TotalMix) of 100-, 200- or 450-fold high end human intake estimates. Mammary glands of prepubertal and adult female and male offspring were examined. Oestrogens increased mammary outgrowth in prepubertal females and the mRNA level of matrix metalloproteinase-3, which may be a potential biomarker for increased outgrowth. Mixtures of EDCs gave rise to ductal hyperplasia in adult males. Adult female mammary glands of the TotalMix group showed morphological changes possibly reflecting increased prolactin levels. In conclusion both estrogenic and anti-androgenic chemicals given during foetal life and lactation affected mammary glands in the offspring. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：47 / 57
页数：11
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