HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide

被引：7
|
作者：
Saez, R [1 ]
Echaniz, P
de Juan, MD
Iribarren, JA
Cuadrado, E
机构：
[1] Hosp Donostia, Secc Inmunol, San Sebastian, Spain
[2] Hosp Donostia, Unidad Enfermedades Infecciosas, San Sebastian, Spain
来源：
AIDS | 2005年 / 19卷 / 16期
关键词：
D O I：
10.1097/01.aids.0000191229.52385.5f
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts.
引用
收藏
页码：1924 / 1925
页数：2
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