HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide

被引：7

作者：

Saez, R ^{[1
]}

Echaniz, P

de Juan, MD

Iribarren, JA

Cuadrado, E

机构：

[1] Hosp Donostia, Secc Inmunol, San Sebastian, Spain

[2] Hosp Donostia, Unidad Enfermedades Infecciosas, San Sebastian, Spain

来源：

AIDS | 2005年 / 19卷 / 16期

关键词：

D O I：

10.1097/01.aids.0000191229.52385.5f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts.

引用

页码：1924 / 1925

页数：2

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