Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy

被引：3
|
作者：
Duncan-Lowey, Jeffrey K. [1 ,2 ]
Chowdhary, Vaidehi [3 ]
Dunne, Dana W. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Med, Sect Infect Dis, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Yale MD PhD Program, New Haven, CT USA
[3] Yale Univ, Sch Med, Dept Med, Sect Rheumatol, New Haven, CT 06510 USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 08期
基金：
美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; autoinflammatory; inflammasome; NLRC4;
D O I：
10.1093/ofid/ofab362
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of autoinflammatory diseases on severe acute respiratory syndrome coronavirus 2 infection remains unknown. We report a case of coronavirus disease 2019 (COVID-19) in a patient with autoinflammation with infantile enterocolitis with inflammatory flares due to a mutation in the inflammasome component NLRC4. This case highlights the role of immunosuppression in patients with autoinflammation with COVID-19.
引用
收藏
页数：4
相关论文
共 50 条
  • [21] Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome
    Barsalou, Julie
    Blincoe, Annaliesse
    Fernandez, Isabel
    Dal-Soglio, Dorothee
    Marchitto, Lorie
    Selleri, Silvia
    Haddad, Elie
    Benyoucef, Aissa
    Touzot, Fabien
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [22] Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019
    Case, Robert
    Ramaniuk, Aliaksandr
    Martin, Pamela
    Simpson, Paul J.
    Harden, Christopher
    Ataya, Ali
    CHEST, 2020, 158 (06) : E267 - E268
  • [23] Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
    Liu, Xuerong
    Bai, Xiaogang
    Zhao, Jing
    Gao, Chaoqun
    Du, Peng
    Zhang, Jin-an
    Li, Sheli
    BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  • [24] NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
    Nichols, Randilea D.
    von Moltke, Jakob
    Vance, Russell E.
    NATURE COMMUNICATIONS, 2017, 8
  • [25] NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
    Randilea D. Nichols
    Jakob von Moltke
    Russell E. Vance
    Nature Communications, 8
  • [26] Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
    Carvalho, F. A.
    Nalbantoglu, I.
    Aitken, J. D.
    Uchiyama, R.
    Su, Y.
    Doho, G. H.
    Vijay-Kumar, M.
    Gewirtz, A. T.
    MUCOSAL IMMUNOLOGY, 2012, 5 (03) : 288 - 298
  • [27] Novel Gene Deletion in NLRC4 Expanding the Familial Cold Inflammatory Syndrome Phenotype
    Jeskey, Jack
    Parida, Akash
    Graven, Kelsey
    Hostoffer, Robert
    ALLERGY & RHINOLOGY, 2020, 11
  • [28] Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus
    Annemarie Steiner
    Thomas Reygaerts
    Alessandra Pontillo
    Isabella Ceccherini
    Jonas Moecking
    Fiona Moghaddas
    Sophia Davidson
    Francesco Caroli
    Alice Grossi
    Fabio Fernandes Morato Castro
    Jorge Kalil
    Florian N. Gohr
    Florian I. Schmidt
    Eva Bartok
    Thomas Zillinger
    Gunther Hartmann
    Matthias Geyer
    Marco Gattorno
    Leonardo Oliveira Mendonça
    Seth L. Masters
    Journal of Clinical Immunology, 2022, 42 : 325 - 335
  • [29] Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus
    Steiner, Annemarie
    Reygaerts, Thomas
    Pontillo, Alessandra
    Ceccherini, Isabella
    Moecking, Jonas
    Moghaddas, Fiona
    Davidson, Sophia
    Caroli, Francesco
    Grossi, Alice
    Morato Castro, Fabio Fernandes
    Kalil, Jorge
    Gohr, Florian N.
    Schmidt, Florian, I
    Bartok, Eva
    Zillinger, Thomas
    Hartmann, Gunther
    Geyer, Matthias
    Gattorno, Marco
    Mendonca, Leonardo Oliveira
    Masters, Seth L.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2022, 42 (02) : 325 - 335
  • [30] An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
    Scott W Canna
    Adriana A de Jesus
    Sushanth Gouni
    Stephen R Brooks
    Bernadette Marrero
    Yin Liu
    Michael A DiMattia
    Kristien J M Zaal
    Gina A Montealegre Sanchez
    Hanna Kim
    Dawn Chapelle
    Nicole Plass
    Yan Huang
    Alejandro V Villarino
    Angelique Biancotto
    Thomas A Fleisher
    Joseph A Duncan
    John J O'Shea
    Susanne Benseler
    Alexei Grom
    Zuoming Deng
    Ronald M Laxer
    Raphaela Goldbach-Mansky
    Nature Genetics, 2014, 46 : 1140 - 1146
12345