An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

被引：7

作者：

Safer, Abdelmounaim ^{[2
]}

Rahmouni, Mustapha ^{[2
]}

Carreaux, Francois ^{[1
]}

Paquin, Ludovic ^{[1
]}

Lozach, Olivier ^{[3
]}

Meijer, Laurent ^{[3
]}

Bazureau, Jean Pierre ^{[1
]}

机构：

[1] Univ Rennes 1, CNRS, Lab Sci Chim Rennes, Grp Ingn Chim & Mol Vivant ICMV,UMR 6226, F-35042 Rennes, France

[2] Univ Ibn Khaldoun, Lab Synth & Catalyse, Tiaret 14000, Algeria

[3] CNRS, Stn Biol Roscoff, F-29682 Roscoff, France

来源：

CHEMICAL PAPERS | 2011年 / 65卷 / 03期

关键词：

rhodanine; isatin; Knoevenagel condensation; solvent-free microwave; ALDOSE REDUCTASE INHIBITOR; AFFINITY-CHROMATOGRAPHY; RHODANINE DERIVATIVES; SELECTIVE INHIBITORS; POTENT; IDENTIFICATION; PURIFICATION; CHEMISTRY;

D O I：

10.2478/s11696-010-0104-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1 alpha/beta, CDK5/p25, and GSK-3 alpha/beta kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 mu M.

引用

页码：332 / 337

页数：6

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