Insight into the catalytic mechanism of thymidylate synthase ThyX of Campylobacter jejuni

被引:0
|
作者
Sodolescu, S. A. [1 ]
Graziani, S. [2 ]
Boum, Y. [3 ]
Myllykallio, H. [3 ]
Liebl, U. [2 ]
机构
[1] Ecole Polytech, Palaiseau, France
[2] LOB Ecole Polytech, Palaiseau, France
[3] Univ Paris 11, UMR, Orsay, France
关键词
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
引用
收藏
页码:55 / 55
页数:1
相关论文
共 50 条
  • [21] A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase
    Kanaan, Natalia
    Marti, Sergio
    Moliner, Vicent
    BIOCHEMISTRY, 2007, 46 (12) : 3704 - 3713
  • [23] Towards the understanding of the catalytic mechanism and substrate specificities of sialyltransferases from Campylobacter jejuni
    Chiu, CPC
    Gilbert, M
    Lairson, LL
    Watts, A
    Wakarchuk, WW
    Withers, SG
    Strynadka, NCJ
    GLYCOBIOLOGY, 2004, 14 (11) : 1123 - 1123
  • [24] Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones
    Skouloubris, Stephane
    Djaout, Kamel
    Lamarre, Isabelle
    Lambry, Jean-Christophe
    Anger, Karine
    Briffotaux, Julien
    Liebl, Ursula
    de Reuse, Hilde
    Myllykallio, Hannu
    OPEN BIOLOGY, 2015, 5 (06):
  • [25] Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX
    Laptenok, Sergey P.
    Bouzhir-Sima, Latifa
    Lambry, Jean-Christophe
    Myllykallio, Hannu
    Liebl, Ursula
    Vos, Marten H.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (22) : 8924 - 8929
  • [26] Active Site Characterization of a Campylobacter jejuni Nitrate Reductase Variant Provides Insight into the Enzyme Mechanism
    Yang, Jing
    Mintmier, Breeanna
    Khadanand, K. C.
    Metzger, Mikayla C.
    Radhakrishnan, Manohar
    McGarry, Jennifer
    Wilcoxen, Jarett
    Basu, Partha
    Kirk, Martin L.
    INORGANIC CHEMISTRY, 2024, 63 (29) : 13191 - 13196
  • [27] Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif
    Ulmer, Jonathan E.
    Boum, Yap
    Thouvenel, Christopher D.
    Myllykallio, Hannu
    Sibley, Carol Hopkins
    JOURNAL OF BACTERIOLOGY, 2008, 190 (06) : 2056 - 2064
  • [28] Molecular dissection of the subvasion mechanism of Campylobacter jejuni
    Van Alphen, L. B.
    Bleumink-Pluym, N. M. C.
    Wosten, M. M. S. M.
    Van Putten, J. P. M.
    ZOONOSES AND PUBLIC HEALTH, 2007, 54 : 86 - 87
  • [29] Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase
    Jarmula, Adam
    Fraczyk, Tomasz
    Cieplak, Piotr
    Rode, Wojciech
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (10) : 3361 - 3370
  • [30] Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1
    Wu, Lian
    Wang, Zhanfeng
    Cen, Yixin
    Wang, Binju
    Zhou, Jiahai
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (12)