Determination of heavy metals in selected drug substances by inductively coupled plasma-mass spectrometry

被引：0
|
作者：
Murty, ASRK [1 ]
Kulshresta, UC [1 ]
Rao, TN [1 ]
Talluri, MVNK [1 ]
机构：
[1] Indian Inst Chem Technol, Div Analyt Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMICAL TECHNOLOGY | 2005年 / 12卷 / 02期
关键词：
inductivity coupled plasma; heavy metal determination; dicycloinineHCl; ethambutol; pyrazinamide; furazolidone;
D O I：
暂无
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Heavy metal contents in dicyclomincHCl, ethambutol, pyrazinamide and furazolidone drugs were determined by inductively coupled plasma (ICP) - mass spectrometry (MS). The drugs Were analyzed for Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg, Pb metals by selecting a suitable isotope. Cr, Fe, Ti and Cu were observed to be highest in dicyclomincHCl, ethambutol, pyrazinamide and furazolidone respectively. Ni and Ha were absent in all the four drugs, while traces of Cd were present in ethambutol and pyrazinamide. Analytical results showed that ICP-MS method is useful for monitoring inorganic impurities present in such drugs.
引用
收藏
页码：229 / 231
页数：3
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