Synthesis and Antiproliferative Evaluation of Spirothiadiazolopyridazine Derivatives

被引：4
|
作者：
Sekkak, Hanan [1 ]
Mojahidi, Souad [1 ]
Rakib, El Mostapha [1 ]
Abouricha, Said [1 ]
Kerbal, Abdelali [2 ]
Aiello, Cinzia [3 ]
Viale, Maurizio [3 ]
机构：
[1] Univ Sultan Moulay Slimane, Lab Chim Organ & Analyt, Fac Sci & Tech, Beni Mellal, Morocco
[2] Univ Sidi Mohammed Ben Abdellah, Fac Sci Dhar El Mehraz, Chim Organ Lab, Dept Chim, Fes, Morocco
[3] Ist Nazl Ric Canc, SC Terapia Immunol, I-16132 Genoa, Italy
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 10期
关键词：
Pyridazinethione; Spirothiadiazolopyridazine; Cytotoxic activity; 1,3-DIPOLAR CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; SPIRO PYRROLIDINES; SPIROHETEROCYCLES; AGENTS;
D O I：
10.2174/1570180811007010743
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 1,3-dipolar cycloaddition of N-aryl-C-ethoxycarbonylnitrile imines to pyridazin-3-thione afforded novel spirothiadiazolopyridazines in moderate to good yields. The reaction occurs regioselectively at the exocyclic C=S bond. Some of the newly synthesized compounds were tested for their in vitro antitumor activity against three human and murine cell lines [human: A2780, (ovary, carcinoma), A549 (lung, carcinoma); murine: P388 (leukaemia)]. Among the series, some compounds exhibited significant growth inhibitory effects against cell lines P388.
引用
收藏
页码：743 / 746
页数：4
相关论文
共 50 条
  • [31] Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents
    Chao, Fan
    Wang, Dong-En
    Liu, Rui
    Tu, Qin
    Liu, Jian-Jun
    Wang, Jinyi
    MOLECULES, 2013, 18 (05): : 5420 - 5433
  • [32] Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents
    Veschi, Serena
    Carradori, Simone
    De Lellis, Laura
    Florio, Rosalba
    Brocco, Davide
    Secci, Daniela
    Guglielmi, Paolo
    Spano, Mattia
    Sobolev, Anatoly P.
    Cama, Alessandro
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) : 1331 - 1344
  • [33] One-Pot Multicomponent Synthesis, Antibacterial and Antiproliferative Evaluation of Indole Derivatives
    Mageed, Ahmed Hassoon
    Mohsin, Muslim Idan
    Al-Sahaf, Sarmad
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (02) : 250 - 264
  • [34] Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents
    Fiorino, Ferdinando
    Magli, Elisa
    Perissutti, Elisa
    Severino, Beatrice
    Frecentese, Francesco
    Esposito, Antonella
    De Angelis, Francesca
    Incisivo, Giuseppina Maria
    Massarelli, Paola
    Nencini, Cristina
    Di Gennaro, Elena
    Budillon, Alfredo
    Di Cintio, Alessandra
    Santagada, Vincenzo
    Caliendo, Giuseppe
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (06) : 2206 - 2216
  • [35] Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives
    Burmaoglu, Serdar
    Aktas Anil, Derya
    Gobek, Arzu
    Kilic, Deryanur
    Yetkin, Derya
    Duran, Nizami
    Algul, Oztekin
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (08): : 3525 - 3550
  • [36] Novel NO-releasing plumbagin derivatives: Design, synthesis and evaluation of antiproliferative activity
    Bao, Na
    Ou, Jinfeng
    Xu, Manyi
    Guan, Fuqin
    Shi, Wei
    Sun, Jianbo
    Chen, Li
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 137 : 88 - 95
  • [37] Design and Synthesis of Novel Triazolyl Benzoxazine Derivatives and Evaluation of Their Antiproliferative and Antibacterial Activity
    Khan, Abdullah
    Prasad, Suchita
    Parmar, Virinder S.
    Sharma, Sunil K.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (04) : 1264 - 1275
  • [38] Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells
    Pyrczak-Felczykowska, Agnieszka
    Narlawar, Rajeshwar
    Pawlik, Anna
    Guzow-Krzeminska, Beata
    Artymiuk, Damian
    Hac, Aleksandra
    Rys, Kamil
    Rendina, Louis M.
    Reekie, Tristan A.
    Herman-Antosiewicz, Anna
    Kassiou, Michael
    JOURNAL OF NATURAL PRODUCTS, 2020, 83 (02): : 563 - 564
  • [39] Synthesis of triazoloquinazolinone derivatives as antiproliferative and antiplatelet aggregation agents and evaluation of their biological effects
    Kobarfard, F.
    Safizadeh, F.
    Amidi, S.
    Ghaffari, S.
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2010, 15 : 181 - 181
  • [40] Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities
    Wang, Wenbin
    He, Yi
    Xu, Pei
    You, Qidong
    Xiao, Hong
    Xiang, Hua
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (15) : 4428 - 4433
12345